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Peer-reviewedCC BY 4.0ACS Omega

Comparative Study of Hypoglycemic Activity of Cr-Gliclazide and Its β-Cyclodextrin Inclusion Complex

  • Khalid Rasheed1
  • Christy Munir1,2
  • Anum Hayat3
  • Amna Yousaf3
  • Faryal Chaudhry3
  • Meerab Fatima3
  1. 1Quaid-e-Azam University , , ,
  2. 2Forman Christian College (A Chartered University) , , Zahoor Elahi Road, Gulberg III , ,
  3. 3Kinnaird College for Women , , 93 Jail Road , ,
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Abstract

This study investigated the synthesis and pharmacological properties of chromium metal complexes with sulfonylureas (hypoglycemic agents). In these complexes, the structural element (chromium) is held within the cavity of the β-cyclodextrin (βCD) molecule. Conditions were optimized for the inclusion complex: 1:1 host–guest ratio, pH = 12, and temperature: ∼25 °C. Cr(III)-Gliclazide (GCZ) and βCD under appropriate experimental conditions show circular dichroism (CD) bands in the visible region: positive Cotton bands at 24,691 cm–1 (Δε = 20.103 degree L mol–1 cm–1) and 16,666 cm–1 (Δε = 26.6 × 10–3 degree L mol–1 cm–1) and a strong negative Cotton band at 19,230 cm–1 (Aε = 38.1 × 10–3 degree L mol–1 cm–1). The synthesized complexes were assessed for their hypoglycemic activity in rabbits with alloxan-induced diabetes. Cr(III)-GCZ showed an early therapeutic response that persisted over an extended duration, while the Cr(III)-GCZ-βCD inclusion complex showed a delayed therapeutic response but maintained an extended duration of activity compared with the reference (parent) drug, gliclazide (GCZ). The synthesized complexes exhibited good therapeutic potential, and the toxicity of these complexes was found to be quite low (high LD50 values).

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Cite

BibTeXRIS
BibTeX
@article{rasheed2026comparative,
  title = {{Comparative Study of Hypoglycemic Activity of Cr-Gliclazide and Its β-Cyclodextrin Inclusion Complex}},
  author = {Khalid Rasheed and Christy Munir and Anum Hayat and Amna Yousaf and Faryal Chaudhry and Meerab Fatima},
  journal = {ACS Omega},
  year = {2026},
  month = oct,
  doi = {10.1021/acsomega.6c09131},
  url = {https://pubs.acs.org/acsodf/article/11/41/64097/5444252/Comparative-Study-of-Hypoglycemic-Activity-of-Cr},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Comparative Study of Hypoglycemic Activity of Cr-Gliclazide and Its β-Cyclodextrin Inclusion Complex
AU  - Khalid Rasheed
AU  - Christy Munir
AU  - Anum Hayat
AU  - Amna Yousaf
AU  - Faryal Chaudhry
AU  - Meerab Fatima
PY  - 2026
DA  - 2026/10/03
JO  - ACS Omega
DO  - 10.1021/acsomega.6c09131
UR  - https://pubs.acs.org/acsodf/article/11/41/64097/5444252/Comparative-Study-of-Hypoglycemic-Activity-of-Cr
AB  - This study investigated the synthesis and pharmacological properties of chromium metal complexes with sulfonylureas (hypoglycemic agents). In these complexes, the structural element (chromium) is held within the cavity of the β-cyclodextrin (βCD) molecule. Conditions were optimized for the inclusion complex: 1:1 host–guest ratio, pH = 12, and temperature: ∼25 °C. Cr(III)-Gliclazide (GCZ) and βCD under appropriate experimental conditions show circular dichroism (CD) bands in the visible region: positive Cotton bands at 24,691 cm–1 (Δε = 20.103 degree L mol–1 cm–1) and 16,666 cm–1 (Δε = 26.6 × 10–3 degree L mol–1 cm–1) and a strong negative Cotton band at 19,230 cm–1 (Aε = 38.1 × 10–3 degree L mol–1 cm–1). The synthesized complexes were assessed for their hypoglycemic activity in rabbits with alloxan-induced diabetes. Cr(III)-GCZ showed an early therapeutic response that persisted over an extended duration, while the Cr(III)-GCZ-βCD inclusion complex showed a delayed therapeutic response but maintained an extended duration of activity compared with the reference (parent) drug, gliclazide (GCZ). The synthesized complexes exhibited good therapeutic potential, and the toxicity of these complexes was found to be quite low (high LD50 values).
SN  - 2470-1343
ER  -