Antioxidant metabolites from the endophytic fungus Aspergillus spelaeus.
Abstract
Five undescribed compounds, including two drimane-type sesquiterpenoids, asperdrimanes A and B (1 and 2), and three amide compounds, asperspamides A-C (3-5), together with four known metabolites 6-9, were isolated from the fungus Aspergillus spelaeus GDGJ-286. By extensively analyzing NMR, LC-MS/MS, Marfey's method, and X-ray crystallography, the structures were characterized successfully. Asperdrimanes A and B (1 and 2) are drimane-type sesquiterpenoids characterized by a spiro-β-lactone moiety. Asperspamide B (4) exhibited exceptional antioxidant capacity in ABTS, FRAP, and DPPH tests, along with significant neuroprotective effects in a hydrogen peroxide-induced PC12 cell oxidative injury model, demonstrating strong anti-apoptotic and anti-necrotic properties. These findings highlight asperspamide B's potential as a lead compound for developing antioxidant agents.
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BibTeX
@article{zhou2026antioxidant,
title = {{Antioxidant metabolites from the endophytic fungus Aspergillus spelaeus.}},
author = {Jia-Tong Zhou and Min Wang and Qian Wu and Min Liang and Wei-Feng Xu and Jun Li and Li-Jun Zhang and Rui-Yun Yang},
journal = {Natural products and bioprospecting},
year = {2026},
month = nov,
doi = {10.1007/s13659-026-00637-9},
url = {https://europepmc.org/article/MED/42970221},
note = {CC BY},
}
RIS
TY - JOUR
TI - Antioxidant metabolites from the endophytic fungus Aspergillus spelaeus.
AU - Jia-Tong Zhou
AU - Min Wang
AU - Qian Wu
AU - Min Liang
AU - Wei-Feng Xu
AU - Jun Li
AU - Li-Jun Zhang
AU - Rui-Yun Yang
PY - 2026
DA - 2026/11/02
JO - Natural products and bioprospecting
DO - 10.1007/s13659-026-00637-9
UR - https://europepmc.org/article/MED/42970221
AB - Five undescribed compounds, including two drimane-type sesquiterpenoids, asperdrimanes A and B (1 and 2), and three amide compounds, asperspamides A-C (3-5), together with four known metabolites 6-9, were isolated from the fungus Aspergillus spelaeus GDGJ-286. By extensively analyzing NMR, LC-MS/MS, Marfey's method, and X-ray crystallography, the structures were characterized successfully. Asperdrimanes A and B (1 and 2) are drimane-type sesquiterpenoids characterized by a spiro-β-lactone moiety. Asperspamide B (4) exhibited exceptional antioxidant capacity in ABTS, FRAP, and DPPH tests, along with significant neuroprotective effects in a hydrogen peroxide-induced PC12 cell oxidative injury model, demonstrating strong anti-apoptotic and anti-necrotic properties. These findings highlight asperspamide B's potential as a lead compound for developing antioxidant agents.
SN - 2192-2195
SN - 2192-2209
ER -