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Peer-reviewedCC BY 4.0ACS Omega

Tuning Molecular Transformations and Accumulation of Reactive Species in Plasma-Treated Liquids via Organic Biomolecules

  • Valeria Veronico1
  • Michele Casiello2
  • Loris Grossi3
  • Roberto Gristina4
  • Vincenza Armenise1
  • Pietro Favia1,4
  • Eloisa Sardella4
4 affiliations
  1. 1Universita degli Studi di Bari Aldo Moro , , via Orabona 4 , ,
  2. 2Istituto di Chimica dei Composti Organo Metallici, Consiglio Nazionale delle Ricerche Sezione di Bari , , Via Orabona 4 , ,
  3. 3Universita degli Studi di Bologna , , Corso d’Augusto, 237 , ,
  4. 4Istituto di Nanotecnologia Consiglio Nazionale delle Ricerche Sede di Bari , , Via Orabona 4 , ,
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Abstract

Plasma processing of liquids is a sustainable platform for green chemistry and biomedical applications, enabling the synthesis of inorganic and organic molecules without harmful reagents and with compatibility with renewable electricity. PTWS constitute reservoirs of reactive oxygen and nitrogen species, and their composition is governed not only by the experimental conditions of the plasma employed for their generation, but also, and predominantly, by the chemical composition of the precursor liquid. In this study, we demonstrate that organic solutes actively modulate RONS chemistry. Phenolic compounds such as l-tyrosine and resorcinol enhance H2O2 production while differently affecting nitrogen species, leading to either scavenging or overproduction of NO2–. Mass spectrometry reveals a strong correlation between molecular structure, plasma-induced modifications, and resulting RONS dynamics. These findings redefine PTWS as dynamic, reactive environments rather than passive reservoirs by also explaining the prolonged activity of such liquids. Beyond plasma medicine, they provide a framework for optimizing RONS-based therapies and contribute to the broader understanding of nonequilibrium chemistry in complex liquids. The results also open opportunities in water treatment and sustainable chemical transformations, positioning PTWS as versatile tools for controlling redox processes in complex aqueous systems.

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Cite

BibTeXRIS
BibTeX
@article{veronico2026tuning,
  title = {{Tuning Molecular Transformations and Accumulation of Reactive Species in Plasma-Treated Liquids via Organic Biomolecules}},
  author = {Valeria Veronico and Michele Casiello and Loris Grossi and Roberto Gristina and Vincenza Armenise and Pietro Favia and Eloisa Sardella},
  journal = {ACS Omega},
  year = {2026},
  month = oct,
  doi = {10.1021/acsomega.6c06500},
  url = {https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c06500/5459334/Tuning-Molecular-Transformations-and-Accumulation},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Tuning Molecular Transformations and Accumulation of Reactive Species in Plasma-Treated Liquids via Organic Biomolecules
AU  - Valeria Veronico
AU  - Michele Casiello
AU  - Loris Grossi
AU  - Roberto Gristina
AU  - Vincenza Armenise
AU  - Pietro Favia
AU  - Eloisa Sardella
PY  - 2026
DA  - 2026/10/27
JO  - ACS Omega
DO  - 10.1021/acsomega.6c06500
UR  - https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c06500/5459334/Tuning-Molecular-Transformations-and-Accumulation
AB  - Plasma processing of liquids is a sustainable platform for green chemistry and biomedical applications, enabling the synthesis of inorganic and organic molecules without harmful reagents and with compatibility with renewable electricity. PTWS constitute reservoirs of reactive oxygen and nitrogen species, and their composition is governed not only by the experimental conditions of the plasma employed for their generation, but also, and predominantly, by the chemical composition of the precursor liquid. In this study, we demonstrate that organic solutes actively modulate RONS chemistry. Phenolic compounds such as l-tyrosine and resorcinol enhance H2O2 production while differently affecting nitrogen species, leading to either scavenging or overproduction of NO2–. Mass spectrometry reveals a strong correlation between molecular structure, plasma-induced modifications, and resulting RONS dynamics. These findings redefine PTWS as dynamic, reactive environments rather than passive reservoirs by also explaining the prolonged activity of such liquids. Beyond plasma medicine, they provide a framework for optimizing RONS-based therapies and contribute to the broader understanding of nonequilibrium chemistry in complex liquids. The results also open opportunities in water treatment and sustainable chemical transformations, positioning PTWS as versatile tools for controlling redox processes in complex aqueous systems.
SN  - 2470-1343
ER  -