Lactic acid bacteria induce regulatory functions in γδ T cells

Abstract

While the immuno-modulatory effects of lactic acid bacteria (LAB) on conventional T cells are well documented, their effects on unconventional T cells, including gamma-delta (γδ) T cells, have not yet been fully characterized. Here, we show that LAB can generate regulatory γδ T cells by significantly increasing interleukin (IL)-10 production relative to stimulation with methicillin-resistant Staphylococcus aureus (MRSA), a pathogenic bacterial strain. This regulatory function subsequently attenuated inflammatory responses in intestinal epithelial cells and immune cells. Thus, LAB can induce regulatory functions in γδ T cells, which may contribute to the maintenance of intestinal health.

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BibTeX RIS

BibTeX

@article{peng2026lactic,
  title = {{Lactic acid bacteria induce regulatory functions in γδ T cells}},
  author = {Zhenzi PENG and Alato OKUNO and Suguru SAITO},
  journal = {Bioscience of Microbiota, Food and Health},
  year = {2026},
  month = sep,
  doi = {10.12938/bmfh.2025-092},
  url = {https://www.jstage.jst.go.jp/article/bmfh/advpub/0/advpub_2025-092/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Lactic acid bacteria induce regulatory functions in γδ T cells
AU  - Zhenzi PENG
AU  - Alato OKUNO
AU  - Suguru SAITO
PY  - 2026
DA  - 2026/09/11
JO  - Bioscience of Microbiota, Food and Health
DO  - 10.12938/bmfh.2025-092
UR  - https://www.jstage.jst.go.jp/article/bmfh/advpub/0/advpub_2025-092/_article
AB  - While the immuno-modulatory effects of lactic acid bacteria (LAB) on conventional T cells are well documented, their effects on unconventional T cells, including gamma-delta (γδ) T cells, have not yet been fully characterized. Here, we show that LAB can generate regulatory γδ T cells by significantly increasing interleukin (IL)-10 production relative to stimulation with methicillin-resistant Staphylococcus aureus (MRSA), a pathogenic bacterial strain. This regulatory function subsequently attenuated inflammatory responses in intestinal epithelial cells and immune cells. Thus, LAB can induce regulatory functions in γδ T cells, which may contribute to the maintenance of intestinal health.
SN  - 2186-3342
ER  -

Abstract

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