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Peer-reviewedCC BY-NCRSC advances

Construction of multifunctional cerium-containing nanozyme hydrogel and its component-level functions in skin wound healing.

  • Xin Bao1
  • Qiyao Tang2
  • Chen Dong3
  • Mingsheng Xu4
  • Xiao Xu1
4 affiliations
  1. 1Yixing People's Hospital/The Affiliated Yixing Hospital of Jiangsu University Jiangsu China [email protected].
  2. 2Shanghai YK PAO High School China.
  3. 3Centre for the Protection of Cultural Property, Ningbo University of Finance & Economic Zhejiang China [email protected].
  4. 4Jiangsu Key Laboratory of Organoid Engineering and Precision Medicine, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences Jiangsu China [email protected].
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Abstract

A multifunctional hydrogel composite incorporating cerium-based nanozymes is developed to modulate the wound microenvironment for skin regeneration. Cerium dioxide (CeO₂) nanoparticles are surface-modified with hyperbranched poly-l-lysine (HBPL), which improves their dispersion and yields a hydrated particle size of approximately 304 nm. These nanozymes are combined with glycyrrhizic acid (GA) and gelatin methacryloyl (GelMA) and crosslinked using visible light to form a CeO₂-HBPL/GA/GelMA hydrogel. The resulting material exhibits tissue adhesion, skin-like mechanical properties, and an irregular porous architecture. In vitro, the hydrogel efficiently scavenges reactive oxygen species (ROS), protects fibroblasts from oxidative damage, and inhibits Escherichia coli (E. coli) growth. It also promotes the polarization of macrophages from a pro-inflammatory (M1) to a pro-healing (M2) phenotype and enhances fibroblast proliferation. In a mouse full-thickness skin defect model, application of the hydrogel promotes wound closure, reduces scarring, and promotes complete epidermal regeneration. Histological analysis reveals decreased inflammatory infiltration and dense, organized collagen deposition resembling healthy skin. This multifunctional dressing integrates antioxidant, anti-inflammatory, and antibacterial activities, providing a proof-of-concept strategy for acute cutaneous wound repair.

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Cite

BibTeXRIS
BibTeX
@article{bao2026construction,
  title = {{Construction of multifunctional cerium-containing nanozyme hydrogel and its component-level functions in skin wound healing.}},
  author = {Xin Bao and Qiyao Tang and Chen Dong and Mingsheng Xu and Xiao Xu},
  journal = {RSC advances},
  year = {2026},
  month = oct,
  doi = {10.1039/d6ra05052b},
  url = {https://europepmc.org/article/MED/42898692},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Construction of multifunctional cerium-containing nanozyme hydrogel and its component-level functions in skin wound healing.
AU  - Xin Bao
AU  - Qiyao Tang
AU  - Chen Dong
AU  - Mingsheng Xu
AU  - Xiao Xu
PY  - 2026
DA  - 2026/10/01
JO  - RSC advances
DO  - 10.1039/d6ra05052b
UR  - https://europepmc.org/article/MED/42898692
AB  - A multifunctional hydrogel composite incorporating cerium-based nanozymes is developed to modulate the wound microenvironment for skin regeneration. Cerium dioxide (CeO₂) nanoparticles are surface-modified with hyperbranched poly-l-lysine (HBPL), which improves their dispersion and yields a hydrated particle size of approximately 304 nm. These nanozymes are combined with glycyrrhizic acid (GA) and gelatin methacryloyl (GelMA) and crosslinked using visible light to form a CeO₂-HBPL/GA/GelMA hydrogel. The resulting material exhibits tissue adhesion, skin-like mechanical properties, and an irregular porous architecture. In vitro, the hydrogel efficiently scavenges reactive oxygen species (ROS), protects fibroblasts from oxidative damage, and inhibits Escherichia coli (E. coli) growth. It also promotes the polarization of macrophages from a pro-inflammatory (M1) to a pro-healing (M2) phenotype and enhances fibroblast proliferation. In a mouse full-thickness skin defect model, application of the hydrogel promotes wound closure, reduces scarring, and promotes complete epidermal regeneration. Histological analysis reveals decreased inflammatory infiltration and dense, organized collagen deposition resembling healthy skin. This multifunctional dressing integrates antioxidant, anti-inflammatory, and antibacterial activities, providing a proof-of-concept strategy for acute cutaneous wound repair.
SN  - 2046-2069
ER  -