PROSPECTIVE COMPARISON OF OPTIMIZED COMPRESSED SENSING AND GRAPPA-ACCELERATED 3D-TOF-MRA FOR EVALUATION OF UNTREATED INTRACRANIAL ANEURYSMS AT 1.5 T: A NON-INFERIORITY STUDY
- 1Institute of Radiology and Neuroradiology, Evangelisches Krankenhaus Oldenburg, Steinweg 13-17, 26122 Oldenburg, Niedersachsen, Germany
Abstract
RATIONALE AND OBJECTIVES 3D-TOF-MRA is a standard non-invasive method for detecting and monitoring intracranial aneurysms, but long scan times remain a limitation. Compressed sensing (CS) acceleration for intracranial aneurysm evaluation has mainly been studied at 3T. This prospective single-center non-inferiority study compared CS-accelerated 3D-TOF at 1.5T with GRAPPA-accelerated 3D-TOF-MRA for evaluating untreated intracranial aneurysms. MATERIALS AND METHODS Sample size was determined via a preliminary retrospective study. 25 patients with 32 untreated aneurysms underwent both CS- (factor 7, 3:04 min) and GRAPPA-accelerated (factor 2, 5:00 min) 3D-TOF, yielding a 38.7% scan-time reduction. Two blinded neuroradiologists assessed overall image quality (primary endpoint) and artifacts, subjective CNR, aneurysm delineation and diameters (secondary endpoints). Non-inferiority was tested via one-sided t-test (prespecified 10% margin); interrater agreement used ICC. RESULTS CS demonstrated non-inferiority to GRAPPA for overall image quality in both readers (p <= .023), though interrater agreement was low (ICC 0.241-0.262), reflecting subjective variability. Secondary exploratory analyses showed heterogeneous preferences. ROI-based CNR was lower for CS (median 169.6; IQR, 91.0-226. vs. 278.2; 181.0-366.2). Aneurysm diameter measurements showed excellent interrater agreement for both techniques (CS ICC, 0.899-0.980; GRAPPA ICC, 0.877-0.973; all p < .001). CONCLUSION CS-accelerated 3D-TOF at 1.5T met non-inferiority criteria vs. GRAPPA-TOF for overall image quality, reducing scan time by 38.7% while preserving aneurysm measurement reliability. However, reduced CNR and reader-preference variability important trade-offs.
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BibTeX
@misc{iacoban2026prospective,
title = {{PROSPECTIVE COMPARISON OF OPTIMIZED COMPRESSED SENSING AND GRAPPA-ACCELERATED 3D-TOF-MRA FOR EVALUATION OF UNTREATED INTRACRANIAL ANEURYSMS AT 1.5 T: A NON-INFERIORITY STUDY}},
author = {C. G. Iacoban and H. Bösenberg and C. Klüner and O. Alykova and M. Gerdes and F. Meinert and B. Sundermann and C. Mathys},
howpublished = {medRxiv},
year = {2026},
month = nov,
doi = {10.64898/2026.11.02.26367077},
url = {https://www.medrxiv.org/content/10.64898/2026.11.02.26367077v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - PROSPECTIVE COMPARISON OF OPTIMIZED COMPRESSED SENSING AND GRAPPA-ACCELERATED 3D-TOF-MRA FOR EVALUATION OF UNTREATED INTRACRANIAL ANEURYSMS AT 1.5 T: A NON-INFERIORITY STUDY
AU - C. G. Iacoban
AU - H. Bösenberg
AU - C. Klüner
AU - O. Alykova
AU - M. Gerdes
AU - F. Meinert
AU - B. Sundermann
AU - C. Mathys
PY - 2026
DA - 2026/11/02
PB - medRxiv
DO - 10.64898/2026.11.02.26367077
UR - https://www.medrxiv.org/content/10.64898/2026.11.02.26367077v1
AB - RATIONALE AND OBJECTIVES 3D-TOF-MRA is a standard non-invasive method for detecting and monitoring intracranial aneurysms, but long scan times remain a limitation. Compressed sensing (CS) acceleration for intracranial aneurysm evaluation has mainly been studied at 3T. This prospective single-center non-inferiority study compared CS-accelerated 3D-TOF at 1.5T with GRAPPA-accelerated 3D-TOF-MRA for evaluating untreated intracranial aneurysms. MATERIALS AND METHODS Sample size was determined via a preliminary retrospective study. 25 patients with 32 untreated aneurysms underwent both CS- (factor 7, 3:04 min) and GRAPPA-accelerated (factor 2, 5:00 min) 3D-TOF, yielding a 38.7% scan-time reduction. Two blinded neuroradiologists assessed overall image quality (primary endpoint) and artifacts, subjective CNR, aneurysm delineation and diameters (secondary endpoints). Non-inferiority was tested via one-sided t-test (prespecified 10% margin); interrater agreement used ICC. RESULTS CS demonstrated non-inferiority to GRAPPA for overall image quality in both readers (p <= .023), though interrater agreement was low (ICC 0.241-0.262), reflecting subjective variability. Secondary exploratory analyses showed heterogeneous preferences. ROI-based CNR was lower for CS (median 169.6; IQR, 91.0-226. vs. 278.2; 181.0-366.2). Aneurysm diameter measurements showed excellent interrater agreement for both techniques (CS ICC, 0.899-0.980; GRAPPA ICC, 0.877-0.973; all p < .001). CONCLUSION CS-accelerated 3D-TOF at 1.5T met non-inferiority criteria vs. GRAPPA-TOF for overall image quality, reducing scan time by 38.7% while preserving aneurysm measurement reliability. However, reduced CNR and reader-preference variability important trade-offs.
ER -