Treatment of myocardial infarction via sodium alginate microsphere-mediated co-delivery of Corydalis yanhusuo ethanolic extract and mesenchymal stem cells.
6 affiliations
- 1Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China.
- 2Phase I Clinical Trial Center, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511400, China.
- 3Department of Pharmacy, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, 510645, China.
- 4Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China. [email protected].
- 5Department of Cardiology, The First Affiliated Hospital of Guangzhou Medical University, China State Key Laboratory for Respiratory Disease, Guangzhou, 510120, China. [email protected].
- 6Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China. [email protected].
Abstract
Persistent inflammatory responses and adverse ventricular remodeling following Acute Myocardial Infarction (MI) are critical factors driving the progressive decline of cardiac function. Traditional pharmacological strategies struggle to achieve effective long-term intervention at the level of tissue repair. The Corydalis yanhusuo ethanolic extract (CYEE) possesses demonstrated anti-inflammatory and antioxidant activities; however, its limited in vivo half-life and the difficulty in maintaining local effective concentrations hinder its efficacy. Concurrently, while mesenchymal stem cells (MSCs) exert therapeutic potential through paracrine and immunomodulatory mechanisms, their low viability within the intensely inflammatory microenvironment of the infarcted myocardium significantly restricts their clinical impact. In this study, a sodium alginate microsphere delivery system was developed using gas-assisted microfluidic technology to achieve the synergistic encapsulation and localized delivery of CYEE and MSCs. This oil-free and surfactant-free microsphere system exhibits excellent biocompatibility, enabling the sustained release of CYEE within the infarcted region to alleviate inflammation and oxidative stress for initial therapeutic intervention. Furthermore, it enhances MSCs viability and paracrine function by optimizing the local microenvironment. In vitro experiments demonstrated that the system significantly improved cell viability under inflammatory conditions and promoted migration and angiogenic capacity. In a rat MI model, synergistic delivery significantly improved cardiac function and attenuated myocardial fibrosis and adverse remodeling without evident systemic toxicity. These results indicate that combining CYEE-mediated microenvironmental regulation with the dynamic synergistic repair of MSCs provides a comprehensive therapeutic strategy with potential translational value for myocardial repair following infarction.
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BibTeX
@article{dang2026treatment,
title = {{Treatment of myocardial infarction via sodium alginate microsphere-mediated co-delivery of Corydalis yanhusuo ethanolic extract and mesenchymal stem cells.}},
author = {Yuanye Dang and Junjie Cai and Yongxian Li and Xudong Qin and Jun Shen and Lian Duan and Qingyun Lu and Xinyue Zhang and Wenqi Xiao and Ruoxuan Liu and Guosheng Tang and Ailan Chen and Huaibin Wang},
journal = {Chinese medicine},
year = {2026},
month = oct,
doi = {10.1186/s13020-026-01557-z},
url = {https://europepmc.org/article/MED/42963558},
note = {CC BY},
}
RIS
TY - JOUR
TI - Treatment of myocardial infarction via sodium alginate microsphere-mediated co-delivery of Corydalis yanhusuo ethanolic extract and mesenchymal stem cells.
AU - Yuanye Dang
AU - Junjie Cai
AU - Yongxian Li
AU - Xudong Qin
AU - Jun Shen
AU - Lian Duan
AU - Qingyun Lu
AU - Xinyue Zhang
AU - Wenqi Xiao
AU - Ruoxuan Liu
AU - Guosheng Tang
AU - Ailan Chen
AU - Huaibin Wang
PY - 2026
DA - 2026/10/30
JO - Chinese medicine
DO - 10.1186/s13020-026-01557-z
UR - https://europepmc.org/article/MED/42963558
AB - Persistent inflammatory responses and adverse ventricular remodeling following Acute Myocardial Infarction (MI) are critical factors driving the progressive decline of cardiac function. Traditional pharmacological strategies struggle to achieve effective long-term intervention at the level of tissue repair. The Corydalis yanhusuo ethanolic extract (CYEE) possesses demonstrated anti-inflammatory and antioxidant activities; however, its limited in vivo half-life and the difficulty in maintaining local effective concentrations hinder its efficacy. Concurrently, while mesenchymal stem cells (MSCs) exert therapeutic potential through paracrine and immunomodulatory mechanisms, their low viability within the intensely inflammatory microenvironment of the infarcted myocardium significantly restricts their clinical impact. In this study, a sodium alginate microsphere delivery system was developed using gas-assisted microfluidic technology to achieve the synergistic encapsulation and localized delivery of CYEE and MSCs. This oil-free and surfactant-free microsphere system exhibits excellent biocompatibility, enabling the sustained release of CYEE within the infarcted region to alleviate inflammation and oxidative stress for initial therapeutic intervention. Furthermore, it enhances MSCs viability and paracrine function by optimizing the local microenvironment. In vitro experiments demonstrated that the system significantly improved cell viability under inflammatory conditions and promoted migration and angiogenic capacity. In a rat MI model, synergistic delivery significantly improved cardiac function and attenuated myocardial fibrosis and adverse remodeling without evident systemic toxicity. These results indicate that combining CYEE-mediated microenvironmental regulation with the dynamic synergistic repair of MSCs provides a comprehensive therapeutic strategy with potential translational value for myocardial repair following infarction.
SN - 1749-8546
ER -