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Peer-reviewedCC BY-NC-NDEnvironment & health (Washington, D.C.)

Mitigating Environmental Pollutant-Induced Premature Ovarian Insufficiency by Rationally Designed Ultrasmall Gold Nanoparticles via Dual Regulation of ROS and Mitophagy.

  • Liyuan Xue1
  • Kai Cao1,2
  • Mingyang Du3
  • Yaqi Jiang2
  • Dongfang Xia1
  • Liang Gao1,2
  • Cuicui Ji3
  • Xueyun Gao1,2
  1. 1College of Materials Science and Engineering, Beijing University of Technology, Beijing 100124, China.
  2. 2Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China.
  3. 3Department of Biology, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China.
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Abstract

Premature ovarian insufficiency (POI), often induced by environmental pollutants such as 4-vinylcyclohexene diepoxide (VCD), is a growing clinical concern, with limited treatment options. Here, we report a nanotherapeutic strategy using a rationally designed ultrasmall gold nanoparticle templated with reduced glutathione (GGNP). GGNPs effectively alleviate VCD-induced granulosa cell aging through scavenging mitochondrial reactive oxygen species and activating mitophagy. This concomitant effect restores mitochondrial function and prevents mitochondrial DNA release, thereby suppressing the downstream STING-mediated senescence-associated secretory phenotype (SASP) pathway. In a VCD-induced POI mouse model, GGNP administration significantly reverses both ovarian and uterine atrophy, normalizes follicle-stimulating hormone levels, and inhibits SASP signaling without detectable toxicity. Our study thus establishes GGNP as a promising nanomedicine for environmental pollutant-induced POI by restoring mitochondrial homeostasis.

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Cite

BibTeXRIS
BibTeX
@article{xue2026mitigating,
  title = {{Mitigating Environmental Pollutant-Induced Premature Ovarian Insufficiency by Rationally Designed Ultrasmall Gold Nanoparticles via Dual Regulation of ROS and Mitophagy.}},
  author = {Liyuan Xue and Kai Cao and Mingyang Du and Yaqi Jiang and Dongfang Xia and Liang Gao and Cuicui Ji and Xueyun Gao},
  journal = {Environment \& health (Washington, D.C.)},
  year = {2026},
  month = jul,
  doi = {10.1021/envhealth.6c00186},
  url = {https://europepmc.org/article/MED/42903735},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Mitigating Environmental Pollutant-Induced Premature Ovarian Insufficiency by Rationally Designed Ultrasmall Gold Nanoparticles via Dual Regulation of ROS and Mitophagy.
AU  - Liyuan Xue
AU  - Kai Cao
AU  - Mingyang Du
AU  - Yaqi Jiang
AU  - Dongfang Xia
AU  - Liang Gao
AU  - Cuicui Ji
AU  - Xueyun Gao
PY  - 2026
DA  - 2026/07/02
JO  - Environment & health (Washington, D.C.)
DO  - 10.1021/envhealth.6c00186
UR  - https://europepmc.org/article/MED/42903735
AB  - Premature ovarian insufficiency (POI), often induced by environmental pollutants such as 4-vinylcyclohexene diepoxide (VCD), is a growing clinical concern, with limited treatment options. Here, we report a nanotherapeutic strategy using a rationally designed ultrasmall gold nanoparticle templated with reduced glutathione (GGNP). GGNPs effectively alleviate VCD-induced granulosa cell aging through scavenging mitochondrial reactive oxygen species and activating mitophagy. This concomitant effect restores mitochondrial function and prevents mitochondrial DNA release, thereby suppressing the downstream STING-mediated senescence-associated secretory phenotype (SASP) pathway. In a VCD-induced POI mouse model, GGNP administration significantly reverses both ovarian and uterine atrophy, normalizes follicle-stimulating hormone levels, and inhibits SASP signaling without detectable toxicity. Our study thus establishes GGNP as a promising nanomedicine for environmental pollutant-induced POI by restoring mitochondrial homeostasis.
SN  - 2833-8278
ER  -