Bioinspired nanozyme-exoskeletonized yeast-derived polysaccharides for treating comorbid anxiety and depression in inflammatory bowel disease
Abstract
Inflammatory bowel disease (IBD) is a chronic condition frequently accompanied by psychological comorbidities, such as anxiety and depression. Although current treatments may alleviate some of these symptoms, the intricate pathogenesis of these comorbidities highlights an urgent need for therapeutic strategies with combined anti-inflammatory, barrier-reparative, and microbiota-modulating effects. Herein, we develop a series of nanozyme-exoskeletonized yeast-derived polysaccharides (NZEP) by integrating nanozymes with yeast-derived polysaccharides using an insect sclerotization-inspired strategy. Among them, NZEP TA-Ce , with the highest degree of nanozyme-exoskeletonization, is capable of disrupting the inflammatory vicious cycle by inhibiting MAPK and NF-κB-mediated inflammatory signaling pathways. Oral administration of NZEP TA-Ce in mice enables effective retention and accumulation in inflamed colonic regions, reverses the homeostasis imbalance of intestinal inflammation and promotes intestinal barrier repair. Furthermore, NZEP TA-Ce treatment reverses gut microbiota dysbiosis and optimizes the composition of microbial metabolites, thereby alleviating anxiety and depressive symptoms associated with IBD. This study provides a safe and promising therapeutic strategy for the management of IBD patients and their associated psychological comorbidities.
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BibTeX
@article{zhang2026bioinspired,
title = {{Bioinspired nanozyme-exoskeletonized yeast-derived polysaccharides for treating comorbid anxiety and depression in inflammatory bowel disease}},
author = {Fan Zhang and Lei Chen and Shengfu Wang and Xinyuan Chen and Kaiyi Du and Fuqiang Song and Linyuan Jiang and Yanzhen Feng and Siting Du and Tianyao Jiang and Yong Liu and Jian Xiao},
journal = {Nature Communications},
year = {2026},
month = oct,
doi = {10.1038/s41467-026-78633-3},
url = {https://www.nature.com/articles/s41467-026-78633-3},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Bioinspired nanozyme-exoskeletonized yeast-derived polysaccharides for treating comorbid anxiety and depression in inflammatory bowel disease
AU - Fan Zhang
AU - Lei Chen
AU - Shengfu Wang
AU - Xinyuan Chen
AU - Kaiyi Du
AU - Fuqiang Song
AU - Linyuan Jiang
AU - Yanzhen Feng
AU - Siting Du
AU - Tianyao Jiang
AU - Yong Liu
AU - Jian Xiao
PY - 2026
DA - 2026/10/14
JO - Nature Communications
DO - 10.1038/s41467-026-78633-3
UR - https://www.nature.com/articles/s41467-026-78633-3
AB - Inflammatory bowel disease (IBD) is a chronic condition frequently accompanied by psychological comorbidities, such as anxiety and depression. Although current treatments may alleviate some of these symptoms, the intricate pathogenesis of these comorbidities highlights an urgent need for therapeutic strategies with combined anti-inflammatory, barrier-reparative, and microbiota-modulating effects. Herein, we develop a series of nanozyme-exoskeletonized yeast-derived polysaccharides (NZEP) by integrating nanozymes with yeast-derived polysaccharides using an insect sclerotization-inspired strategy. Among them, NZEP TA-Ce , with the highest degree of nanozyme-exoskeletonization, is capable of disrupting the inflammatory vicious cycle by inhibiting MAPK and NF-κB-mediated inflammatory signaling pathways. Oral administration of NZEP TA-Ce in mice enables effective retention and accumulation in inflamed colonic regions, reverses the homeostasis imbalance of intestinal inflammation and promotes intestinal barrier repair. Furthermore, NZEP TA-Ce treatment reverses gut microbiota dysbiosis and optimizes the composition of microbial metabolites, thereby alleviating anxiety and depressive symptoms associated with IBD. This study provides a safe and promising therapeutic strategy for the management of IBD patients and their associated psychological comorbidities.
SN - 2041-1723
ER -