Advanced Cobalt Nanocatalyst on Covalently Functionalized Halloysite for Alkoxy- and Aminocarbonylations
Abstract
Herein, we report the design of a bifunctional nanocatalyst comprising cobalt nanoparticles (CoNPs) and covalently functionalized halloysite nanotubes with peralkylguanidine moieties (HAL-PAG) for alkoxy-and aminocarbonylation processes mediated via dual catalysis. The nano-tubular morphology of naturally occurring halloysite, combined with peralkylguanidine functionalization, promotes efficient nanoparticles distribution on the support, avoiding agglomeration. Full characterization of the innovative nanomaterials confirms both the successful immobilization and the chemical environment of the CoNPs. Under optimized conditions, the CoNPs@HAL-PAG catalyst enables the alkoxy and amino-carbonylation of iodoarenes to the corresponding esters and amides respectively, in high yields (up to 80%), significantly improved in comparison with the non-functionalized CoNPs@HAL catalytic material. CoNPs@HAL-PAG exhibits broad substrate scope across various aryl iodides and alcohols and amines, including the synthesis of the blockbuster drug benzocaine. To the best of our knowledge, this represents one of the first examples of supported dual systems, encompassing both peralkylguanidine as a strong proton acceptor, and non-noble metalbased nanoparticles applied to the alkoxy-and aminocarbonylations of aryl halides. This system offers a robust and recyclable catalyst for the sustainable synthesis of aryl esters and amides.
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BibTeX
@article{carmonachavez2026advanced,
title = {{Advanced Cobalt Nanocatalyst on Covalently Functionalized Halloysite for Alkoxy- and Aminocarbonylations}},
author = {Rodrigo Carmona-Chávez and Karla P Salas-Martin and Alejandro Serrano-Maldonado and Jérôme Esvan and Itzel Guerrero-Ríos and Montserrat Gómez and Antonio Reina and Daniel Pla},
journal = {ACS Applied Nano Materials},
year = {2026},
month = oct,
doi = {10.1021/acsanm.6c03990},
url = {https://hal.science/hal-05803785v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Advanced Cobalt Nanocatalyst on Covalently Functionalized Halloysite for Alkoxy- and Aminocarbonylations
AU - Rodrigo Carmona-Chávez
AU - Karla P Salas-Martin
AU - Alejandro Serrano-Maldonado
AU - Jérôme Esvan
AU - Itzel Guerrero-Ríos
AU - Montserrat Gómez
AU - Antonio Reina
AU - Daniel Pla
PY - 2026
DA - 2026/10/19
JO - ACS Applied Nano Materials
DO - 10.1021/acsanm.6c03990
UR - https://hal.science/hal-05803785v1
AB - Herein, we report the design of a bifunctional nanocatalyst comprising cobalt nanoparticles (CoNPs) and covalently functionalized halloysite nanotubes with peralkylguanidine moieties (HAL-PAG) for alkoxy-and aminocarbonylation processes mediated via dual catalysis. The nano-tubular morphology of naturally occurring halloysite, combined with peralkylguanidine functionalization, promotes efficient nanoparticles distribution on the support, avoiding agglomeration. Full characterization of the innovative nanomaterials confirms both the successful immobilization and the chemical environment of the CoNPs. Under optimized conditions, the CoNPs@HAL-PAG catalyst enables the alkoxy and amino-carbonylation of iodoarenes to the corresponding esters and amides respectively, in high yields (up to 80%), significantly improved in comparison with the non-functionalized CoNPs@HAL catalytic material. CoNPs@HAL-PAG exhibits broad substrate scope across various aryl iodides and alcohols and amines, including the synthesis of the blockbuster drug benzocaine. To the best of our knowledge, this represents one of the first examples of supported dual systems, encompassing both peralkylguanidine as a strong proton acceptor, and non-noble metalbased nanoparticles applied to the alkoxy-and aminocarbonylations of aryl halides. This system offers a robust and recyclable catalyst for the sustainable synthesis of aryl esters and amides.
SN - 2574-0970
ER -