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Peer-reviewedLicence not statedNature

In vivo genome-wide CRISPR screens of human T cells in solid tumours

  • Qi Liu1,2
  • Peixin Amy Chen3,4
  • Esha Urs3,4
  • Shimin Zhang4
  • Maya M. Arce3,4
  • Charlotte H. Wang3,4
  • Jun Yan3,4
  • Vinh Q. Nguyen3,5,6,4,7
  • Zhongmei Li3,4
  • Jin Seo3,4
  • Nupura Kale3,4
  • Fanglue Peng8
21 more authors
  • Yikai Luo3,4
  • Laine Goudy3,4
  • Taylor N. LaFlam8,9
  • Haixia Zhong3
  • Chandrima Modak4
  • Emma Dann10,4
  • Jae Hyung Jung3,4
  • Amanda Kirane11
  • Allison Betof Warner12
  • Boi Bryant Quach13,14
  • Zinaida Good13,14,15,16
  • Brian Rudolph Shy17,4,18,16
  • Eric Shifrut19,20,21
  • Sagar P. Bapat22,16
  • Greg M. Allen3,15,18,16
  • Justin Eyquem3,4,15,16
  • Katherine Cynthia Fuh23
  • Stacie E. Dodgson4
  • Jason G. Cyster8
  • Alexander Marson3,24,4,25,26,15,18,16
  • Julia C. Carnevale27,28,29,30,31
31 affiliations
  1. 1Department of Medicine, University of California San Francisco, San Francisco, CA, USA. [email protected]
  2. 2Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. [email protected]
  3. 3Department of Medicine, University of California San Francisco, San Francisco, CA, USA
  4. 4Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA
  5. 5Department of Surgery, University of California San Francisco, San Francisco, CA, USA
  6. 6Diabetes Center, University of California San Francisco, San Francisco, CA, USA
  7. 7UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA
  8. 8Department of Microbiology and Immunology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA
  9. 9Division of Pediatric Rheumatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
  10. 10Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
  11. 11Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
  12. 12Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
  13. 13Division of Computational Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
  14. 14Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA
  15. 15Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA
  16. 16Weill Cancer Hub West, Stanford University and University of California, San Francisco, CA, USA
  17. 17Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA
  18. 18UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA
  19. 19Dotan Center for Advanced Therapies, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
  20. 20George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
  21. 21Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel
  22. 22Department of Pathology, University of California San Francisco, San Francisco, CA, USA
  23. 23Department of OB/Gyn, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA
  24. 24Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA
  25. 25Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, USA
  26. 26Institute for Human Genetics (IHG), University of California San Francisco, San Francisco, CA, USA
  27. 27Department of Medicine, University of California San Francisco, San Francisco, CA, USA. [email protected]
  28. 28Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. [email protected]
  29. 29Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. [email protected]
  30. 30UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. [email protected]
  31. 31Weill Cancer Hub West, Stanford University and University of California, San Francisco, CA, USA. [email protected]
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Cite

BibTeXRIS
BibTeX
@article{liu2026vivo,
  title = {{In vivo genome-wide CRISPR screens of human T cells in solid tumours}},
  author = {Qi Liu and Peixin Amy Chen and Esha Urs and Shimin Zhang and Maya M. Arce and Charlotte H. Wang and Jun Yan and Vinh Q. Nguyen and Zhongmei Li and Jin Seo and Nupura Kale and Fanglue Peng and Yikai Luo and Laine Goudy and Taylor N. LaFlam and Haixia Zhong and Chandrima Modak and Emma Dann and Jae Hyung Jung and Amanda Kirane and Allison Betof Warner and Boi Bryant Quach and Zinaida Good and Brian Rudolph Shy and Eric Shifrut and Sagar P. Bapat and Greg M. Allen and Justin Eyquem and Katherine Cynthia Fuh and Stacie E. Dodgson and Jason G. Cyster and Alexander Marson and Julia C. Carnevale},
  journal = {Nature},
  year = {2026},
  month = aug,
  doi = {10.1038/s41586-026-10906-9},
  url = {https://doi.org/10.1101/2025.09.23.678127},
}
RIS
TY  - JOUR
TI  - In vivo genome-wide CRISPR screens of human T cells in solid tumours
AU  - Qi Liu
AU  - Peixin Amy Chen
AU  - Esha Urs
AU  - Shimin Zhang
AU  - Maya M. Arce
AU  - Charlotte H. Wang
AU  - Jun Yan
AU  - Vinh Q. Nguyen
AU  - Zhongmei Li
AU  - Jin Seo
AU  - Nupura Kale
AU  - Fanglue Peng
AU  - Yikai Luo
AU  - Laine Goudy
AU  - Taylor N. LaFlam
AU  - Haixia Zhong
AU  - Chandrima Modak
AU  - Emma Dann
AU  - Jae Hyung Jung
AU  - Amanda Kirane
AU  - Allison Betof Warner
AU  - Boi Bryant Quach
AU  - Zinaida Good
AU  - Brian Rudolph Shy
AU  - Eric Shifrut
AU  - Sagar P. Bapat
AU  - Greg M. Allen
AU  - Justin Eyquem
AU  - Katherine Cynthia Fuh
AU  - Stacie E. Dodgson
AU  - Jason G. Cyster
AU  - Alexander Marson
AU  - Julia C. Carnevale
PY  - 2026
DA  - 2026/08/12
JO  - Nature
DO  - 10.1038/s41586-026-10906-9
UR  - https://doi.org/10.1101/2025.09.23.678127
SN  - 0028-0836
SN  - 1476-4687
ER  -