Age-specific trends in poisoning-related out-of-hospital cardiac arrest in Japan: a retrospective nationwide registry study.
- 1Department of Clinical Toxicology, Saitama Medical University, 38 Moro-hongo, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.
Abstract
Aim
Poisoning-related out-of-hospital cardiac arrest (OHCA) may have distinct age-specific trends. We examined temporal changes in its proportion among all OHCA, population-based incidence, and neurological outcomes in Japan.Methods
In this retrospective nationwide registry study, we analyzed adults aged ≥18 years OHCA treated by emergency medical services (EMS) in the Japanese Utstein registry from 2013 to 2023. Age-specific logistic regression estimated annual trends in the proportion of poisoning-related OHCA, adjusted for age and sex. Poisson regression with age-group population as the exposure estimated incidence trends. Neurological outcome trends were examined secondarily.Results
Among 1,400,951 adults with OHCA treated by EMS, 3723 (0.27%) had poisoning-related OHCA. In adults aged 18-29 years, the adjusted odds of poisoning-related OHCA increased (odds ratio per year, 1.027; 95% CI, 1.001-1.054), whereas population-based incidence showed a nonsignificant upward trend (incidence rate ratio, 1.020; 95% CI, 0.995-1.046). All-cause OHCA incidence declined among adults aged 18-29 years (incidence rate ratio, 0.991; 95% CI, 0.983-0.9997). The poisoning proportion decreased at ages 50-64 and ≥65 years; poisoning incidence declined significantly only at ≥65 years. Favorable neurological outcome after poisoning-related OHCA showed no clear improvement (adjusted odds ratio per year, 0.998; 95% CI, 0.949-1.050).Conclusion
Poisoning-related OHCA became increasingly prominent among young adults but declined among older adults. Although the incidence increase in young adults was not statistically significant, its upward direction, declining all-cause OHCA incidence, and lack of clear neurological outcome improvement suggest increasing clinical importance of poisoning-related OHCA in young adults.
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BibTeX
@article{chiba2026agespecific,
title = {{Age-specific trends in poisoning-related out-of-hospital cardiac arrest in Japan: a retrospective nationwide registry study.}},
author = {Takuyo Chiba and Ryoko Kyan and Michiko Takai and Tomohisa Nagayama and Kurumi Mori and Yoshito Kamijo},
journal = {Resuscitation plus},
year = {2026},
month = oct,
doi = {10.1016/j.resplu.2026.101522},
url = {https://europepmc.org/article/MED/42927144},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Age-specific trends in poisoning-related out-of-hospital cardiac arrest in Japan: a retrospective nationwide registry study.
AU - Takuyo Chiba
AU - Ryoko Kyan
AU - Michiko Takai
AU - Tomohisa Nagayama
AU - Kurumi Mori
AU - Yoshito Kamijo
PY - 2026
DA - 2026/10/06
JO - Resuscitation plus
DO - 10.1016/j.resplu.2026.101522
UR - https://europepmc.org/article/MED/42927144
AB - Aim Poisoning-related out-of-hospital cardiac arrest (OHCA) may have distinct age-specific trends. We examined temporal changes in its proportion among all OHCA, population-based incidence, and neurological outcomes in Japan.Methods In this retrospective nationwide registry study, we analyzed adults aged ≥18 years OHCA treated by emergency medical services (EMS) in the Japanese Utstein registry from 2013 to 2023. Age-specific logistic regression estimated annual trends in the proportion of poisoning-related OHCA, adjusted for age and sex. Poisson regression with age-group population as the exposure estimated incidence trends. Neurological outcome trends were examined secondarily.Results Among 1,400,951 adults with OHCA treated by EMS, 3723 (0.27%) had poisoning-related OHCA. In adults aged 18-29 years, the adjusted odds of poisoning-related OHCA increased (odds ratio per year, 1.027; 95% CI, 1.001-1.054), whereas population-based incidence showed a nonsignificant upward trend (incidence rate ratio, 1.020; 95% CI, 0.995-1.046). All-cause OHCA incidence declined among adults aged 18-29 years (incidence rate ratio, 0.991; 95% CI, 0.983-0.9997). The poisoning proportion decreased at ages 50-64 and ≥65 years; poisoning incidence declined significantly only at ≥65 years. Favorable neurological outcome after poisoning-related OHCA showed no clear improvement (adjusted odds ratio per year, 0.998; 95% CI, 0.949-1.050).Conclusion Poisoning-related OHCA became increasingly prominent among young adults but declined among older adults. Although the incidence increase in young adults was not statistically significant, its upward direction, declining all-cause OHCA incidence, and lack of clear neurological outcome improvement suggest increasing clinical importance of poisoning-related OHCA in young adults.
SN - 2666-5204
ER -