Earlier onset of type 2 diabetes mellitus as a risk factor for Irvine-Gass syndrome.
- 1Department of Ophthalmology, Beijing Geriatric Hospital, Beijing, China.
- 2Beijing Tsinghua Changgung Hospital Eye Center, Beijing Visual Science and Translational Eye Research Institute (BERI), Tsinghua Medicine, Tsinghua University, Beijing, China.
- 3Beijing Tsinghua Changgung Hospital Eye Center, Beijing Visual Science and Translational Eye Research Institute (BERI), Tsinghua Medicine, Tsinghua University, Beijing, China. Electronic address: [email protected].
Abstract
Purpose
To investigate the association between age at type 2 diabetes mellitus (T2DM) onset and the risk of Irvine-Gass Syndrome (IGS) following uneventful phacoemulsification with intraocular lens implantation (PEI).Methods
This retrospective case-control study analyzed 190 participants (39 IGS, 151 non-IGS) who underwent uneventful PEI. Comprehensive demographic, systemic, and perioperative data were collected. Statistical analyses included between-group comparisons, logistic regression, and Receiver Operating Characteristic (ROC) curve analysis to identify independent IGS predictors and determine optimal risk-stratification thresholds.Results
While overall T2DM prevalence was comparable between groups (p = 0.168), IGS patients had significantly earlier diabetes onset (49.05±8.61 vs. 59.23±10.65 years, p < 0.001). Multivariable analysis confirmed younger T2DM onset age as an independent IGS predictor (OR = 1.094 per year decrease, 95% Confidence Interval [95% CI 1.015‒1.179], p = 0.019). ROC analysis identified T2DM onset age ≤ 55.5-years as the optimal predictive threshold (Area Under the ROC Curve [AUROC = 0.774], sensitivity = 73.7%, specificity = 78.9%). Participants stratified by this threshold showed significantly different IGS incidence (non-diabetic: 15.32%; younger-onset T2DM: 56.67%; older-onset T2DM: 10.20%; p < 0.001). Younger-onset T2DM patients had approximately 5.5-fold higher IGS odds versus non-diabetics (adjusted OR = 5.499, 95% CI 2.104‒14.373, p = 0.001).Conclusions
Earlier T2DM onset (≤ 55.5-years) is a strong independent risk factor for IGS following uneventful PEI. This threshold provides a clinically useful tool for preoperative risk stratification, particularly valuable for identifying high-risk diabetic patients who may benefit from enhanced perioperative monitoring and management.
Related
- Concentrated growth factor in combination with insulin for improving type 2 diabetes mellitus alveolar bone regeneration: a pilot study
- Limited Joint Mobility Syndrome Mimicking Rheumatoid Arthritis in a Patient with Type 2 Diabetes Mellitus: A Case Report
- Interconnected metabolic and reproductive signaling axis in type 2 diabetes mellitus and polyendocrine metabolic ovarian syndrome
- Serum insulin-like growth factor-1 is lower in children with type 1 and type 2 diabetes mellitus than in a non-diabetic comparison group after adjustment for age and sex: a cross-sectional study
- Prevalence of Factor V Leiden mutation in yemeni women with gestational diabetes mellitus and recurrent pregnancy loss: a case-control study.
BibTeX
@article{yin2026earlier,
title = {{Earlier onset of type 2 diabetes mellitus as a risk factor for Irvine-Gass syndrome.}},
author = {Yingxia Yin and Yu Du and Junyi Wang and Wan Lu and Shancheng Si},
journal = {Clinics (Sao Paulo, Brazil)},
year = {2026},
month = oct,
doi = {10.1016/j.clinsp.2026.101204},
url = {https://europepmc.org/article/MED/42874505},
note = {CC BY},
}
RIS
TY - JOUR
TI - Earlier onset of type 2 diabetes mellitus as a risk factor for Irvine-Gass syndrome.
AU - Yingxia Yin
AU - Yu Du
AU - Junyi Wang
AU - Wan Lu
AU - Shancheng Si
PY - 2026
DA - 2026/10/14
JO - Clinics (Sao Paulo, Brazil)
DO - 10.1016/j.clinsp.2026.101204
UR - https://europepmc.org/article/MED/42874505
AB - Purpose To investigate the association between age at type 2 diabetes mellitus (T2DM) onset and the risk of Irvine-Gass Syndrome (IGS) following uneventful phacoemulsification with intraocular lens implantation (PEI).Methods This retrospective case-control study analyzed 190 participants (39 IGS, 151 non-IGS) who underwent uneventful PEI. Comprehensive demographic, systemic, and perioperative data were collected. Statistical analyses included between-group comparisons, logistic regression, and Receiver Operating Characteristic (ROC) curve analysis to identify independent IGS predictors and determine optimal risk-stratification thresholds.Results While overall T2DM prevalence was comparable between groups (p = 0.168), IGS patients had significantly earlier diabetes onset (49.05±8.61 vs. 59.23±10.65 years, p < 0.001). Multivariable analysis confirmed younger T2DM onset age as an independent IGS predictor (OR = 1.094 per year decrease, 95% Confidence Interval [95% CI 1.015‒1.179], p = 0.019). ROC analysis identified T2DM onset age ≤ 55.5-years as the optimal predictive threshold (Area Under the ROC Curve [AUROC = 0.774], sensitivity = 73.7%, specificity = 78.9%). Participants stratified by this threshold showed significantly different IGS incidence (non-diabetic: 15.32%; younger-onset T2DM: 56.67%; older-onset T2DM: 10.20%; p < 0.001). Younger-onset T2DM patients had approximately 5.5-fold higher IGS odds versus non-diabetics (adjusted OR = 5.499, 95% CI 2.104‒14.373, p = 0.001).Conclusions Earlier T2DM onset (≤ 55.5-years) is a strong independent risk factor for IGS following uneventful PEI. This threshold provides a clinically useful tool for preoperative risk stratification, particularly valuable for identifying high-risk diabetic patients who may benefit from enhanced perioperative monitoring and management.
SN - 1807-5932
SN - 1980-5322
ER -