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Peer-reviewedCC BYEngMedicine

A 3D-printed composite scaffold with sequential delivery of QK and osteogenic growth peptides promotes diabetic bone regeneration through angiogenic and osteogenic modulation

  • Hantao Yang1
  • Yansong Dong2
  • Jun Chen3
  • Zecai Chen2
  • Zhen Xu2
  • Xuandu Chen2
  • Yafang Huang4
  • Weihong Yi2
  • Wenzhao Wang5
  • Qingsong Zhang6
  • Jie Tan
6 affiliations
  1. 1Orthopaedic Laboratory, Wuhan Fourth Hospital, Wuhan, 430033, China; Department of Spine Surgery & Innovative Laboratory of Orthopedics, Shenzhen Nanshan People's Hospital, The Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, 518052, China; Department of Orthopedic Department, Jiading District Central Hospital, Shanghai, 201800, China
  2. 2Department of Spine Surgery & Innovative Laboratory of Orthopedics, Shenzhen Nanshan People's Hospital, The Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, 518052, China
  3. 3Orthopaedic Laboratory, Wuhan Fourth Hospital, Wuhan, 430033, China; Hubei Provincial Sports Medicine Center, Hubei Provincial Clinical Research Center for Orthopaedics, Hubei Key Laboratory of Sports Injury and Precision Therapy, Wuhan, 430033, China
  4. 4Hubei Provincial Sports Medicine Center, Hubei Provincial Clinical Research Center for Orthopaedics, Hubei Key Laboratory of Sports Injury and Precision Therapy, Wuhan, 430033, China
  5. 5Department of Orthopedic, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China; School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, 999077, Hong Kong Special Administrative Region of China; Corresponding author. Department of Orthopedic, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
  6. 6Orthopaedic Laboratory, Wuhan Fourth Hospital, Wuhan, 430033, China; Hubei Provincial Sports Medicine Center, Hubei Provincial Clinical Research Center for Orthopaedics, Hubei Key Laboratory of Sports Injury and Precision Therapy, Wuhan, 430033, China; Corresponding author. Orthopedic Department & Hubei Sports Medicine Center, Wuhan Fourth Hospital, Wuhan, 430030, China.
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Abstract

Diabetic bone defects heal poorly due to hyperglycemia-induced impairments in osteogenesis and angiogenesis, which may lead to delayed regeneration if left untreated. To address these challenges, we developed a composite 3D-printed poly(lactic-co-glycolic acid)/hydroxyapatite (HA) scaffold functionalized with the orchestrated release of vascular endothelial growth factor-mimetic peptide (QK) and osteogenic growth peptide (OGP). The unique triphasic release profile of the scaffold was engineered to mimic natural bone-healing cascades: (1) the initial rapid release of QK peptides resulting from degradation of the dextran methacrylate coating initiates angiogenesis, thereby addressing the critical vascular deficiency; (2) the subsequent sustained release of OGP stimulates osteoblast differentiation and bone formation; and (3) the prolonged release of Ca 2+ and PO 4 3− from nano-HA particles supports matrix mineralization and structural integrity. This spatiotemporally coordinated delivery system surpasses conventional single-factor approaches by simultaneously addressing the multiple pathological features of diabetic bone abnormalities. In-vitro and in-vivo evaluations validated the sequential release kinetics of the scaffold that effectively couple vascularization and osteogenesis, establishing a regenerative milieu that mitigates diabetes-impaired healing deficiencies. The coordinated actions of these components not only offer an alternate therapeutic strategy for diabetic bone defects but also hold potential for application in other complex tissue-regeneration scenarios requiring coordinated multicellular responses.

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Cite

BibTeXRIS
BibTeX
@article{yang20263dprinted,
  title = {{A 3D-printed composite scaffold with sequential delivery of QK and osteogenic growth peptides promotes diabetic bone regeneration through angiogenic and osteogenic modulation}},
  author = {Hantao Yang and Yansong Dong and Jun Chen and Zecai Chen and Zhen Xu and Xuandu Chen and Yafang Huang and Weihong Yi and Wenzhao Wang and Qingsong Zhang and Jie Tan},
  journal = {EngMedicine},
  year = {2026},
  month = oct,
  doi = {10.1016/j.engmed.2026.100163},
  url = {https://doi.org/10.1016/j.engmed.2026.100163},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - A 3D-printed composite scaffold with sequential delivery of QK and osteogenic growth peptides promotes diabetic bone regeneration through angiogenic and osteogenic modulation
AU  - Hantao Yang
AU  - Yansong Dong
AU  - Jun Chen
AU  - Zecai Chen
AU  - Zhen Xu
AU  - Xuandu Chen
AU  - Yafang Huang
AU  - Weihong Yi
AU  - Wenzhao Wang
AU  - Qingsong Zhang
AU  - Jie Tan
PY  - 2026
DA  - 2026/10/30
JO  - EngMedicine
DO  - 10.1016/j.engmed.2026.100163
UR  - https://doi.org/10.1016/j.engmed.2026.100163
AB  - Diabetic bone defects heal poorly due to hyperglycemia-induced impairments in osteogenesis and angiogenesis, which may lead to delayed regeneration if left untreated. To address these challenges, we developed a composite 3D-printed poly(lactic-co-glycolic acid)/hydroxyapatite (HA) scaffold functionalized with the orchestrated release of vascular endothelial growth factor-mimetic peptide (QK) and osteogenic growth peptide (OGP). The unique triphasic release profile of the scaffold was engineered to mimic natural bone-healing cascades: (1) the initial rapid release of QK peptides resulting from degradation of the dextran methacrylate coating initiates angiogenesis, thereby addressing the critical vascular deficiency; (2) the subsequent sustained release of OGP stimulates osteoblast differentiation and bone formation; and (3) the prolonged release of Ca 2+ and PO 4 3− from nano-HA particles supports matrix mineralization and structural integrity. This spatiotemporally coordinated delivery system surpasses conventional single-factor approaches by simultaneously addressing the multiple pathological features of diabetic bone abnormalities. In-vitro and in-vivo evaluations validated the sequential release kinetics of the scaffold that effectively couple vascularization and osteogenesis, establishing a regenerative milieu that mitigates diabetes-impaired healing deficiencies. The coordinated actions of these components not only offer an alternate therapeutic strategy for diabetic bone defects but also hold potential for application in other complex tissue-regeneration scenarios requiring coordinated multicellular responses.
SN  - 2950-4899
ER  -