Eosinophilic Gastroenteritis during Tocilizumab Treatment for Castleman Disease

Abstract

Eosinophilic gastroenteritis (EGE) is a rare inflammatory disorder characterized by eosinophilic infiltration of the gastrointestinal tract and its associated symptoms. We report a case of EGE in a patient with idiopathic multicentric Castleman disease and asthma, who developed gastrointestinal symptoms and eosinophilia during tocilizumab therapy. Endoscopy revealed marked gastric mucosal injury and biopsy confirmed eosinophilic infiltration. Despite normal intestinal endoscopic findings, the biopsy specimens revealed eosinophilic infiltration. The discontinuation of tocilizumab and initiation of prednisolone resulted in complete symptom resolution, suggesting that the onset of EGE may have been associated with tocilizumab treatment.

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BibTeX RIS

BibTeX

@article{kaneko2026eosinophilic,
  title = {{Eosinophilic Gastroenteritis during Tocilizumab Treatment for Castleman Disease}},
  author = {Hiromitsu Kaneko and Kenta Hayashino and Hiroki Kobayashi and Yuki Fujiwara and Takeru Aasano and Shoka Kimura and Machiko Hotta and Kenji Takashima and Yasushi Hiramatsu},
  journal = {Internal Medicine},
  year = {2026},
  month = oct,
  doi = {10.2169/internalmedicine.6661-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6661-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Eosinophilic Gastroenteritis during Tocilizumab Treatment for Castleman Disease
AU  - Hiromitsu Kaneko
AU  - Kenta Hayashino
AU  - Hiroki Kobayashi
AU  - Yuki Fujiwara
AU  - Takeru Aasano
AU  - Shoka Kimura
AU  - Machiko Hotta
AU  - Kenji Takashima
AU  - Yasushi Hiramatsu
PY  - 2026
DA  - 2026/10/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6661-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6661-25/_article
AB  - Eosinophilic gastroenteritis (EGE) is a rare inflammatory disorder characterized by eosinophilic infiltration of the gastrointestinal tract and its associated symptoms. We report a case of EGE in a patient with idiopathic multicentric Castleman disease and asthma, who developed gastrointestinal symptoms and eosinophilia during tocilizumab therapy. Endoscopy revealed marked gastric mucosal injury and biopsy confirmed eosinophilic infiltration. Despite normal intestinal endoscopic findings, the biopsy specimens revealed eosinophilic infiltration. The discontinuation of tocilizumab and initiation of prednisolone resulted in complete symptom resolution, suggesting that the onset of EGE may have been associated with tocilizumab treatment.
SN  - 1349-7235
SN  - 0918-2918
ER  -

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