Peer-reviewedCC BYOrganic letters
Iron-Catalyzed Defluorinative Alkylation for Accessing Cyclic Acetal-gem-Difluoroalkenes.
- 1State Key Laboratory of Synthetic Chemistry and Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Abstract
Cyclic acetals and gem-difluoroalkenes are proven structural motifs in medicinal chemistry, yet their modular incorporation into a densely functionalized hybrid architecture remains an uncharted frontier. Herein, we disclose an Fe-catalyzed reductive defluorinative cross-coupling between trifluoromethyl alkenes and 1,3-dioxolanyl- or 1,3-dioxepanyl-substituted alkyl iodides, enabling the rapid assembly of five- or seven-membered cyclic acetal-embodied fluorinated scaffolds, respectively. This protocol enriches defluorinative coupling versatility and offers streamlined access to structurally diverse pharmaceutically relevant scaffolds.
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BibTeX
@article{wang2026ironcatalyzed,
title = {{Iron-Catalyzed Defluorinative Alkylation for Accessing Cyclic Acetal-gem-Difluoroalkenes.}},
author = {Xiao-Tong Wang and Pui Ying Choy and Chi Wai Cheung and Fuk Yee Kwong},
journal = {Organic letters},
year = {2026},
month = oct,
doi = {10.1021/acs.orglett.6c03239},
url = {https://europepmc.org/article/MED/42917824},
note = {CC BY},
}
RIS
TY - JOUR
TI - Iron-Catalyzed Defluorinative Alkylation for Accessing Cyclic Acetal-gem-Difluoroalkenes.
AU - Xiao-Tong Wang
AU - Pui Ying Choy
AU - Chi Wai Cheung
AU - Fuk Yee Kwong
PY - 2026
DA - 2026/10/01
JO - Organic letters
DO - 10.1021/acs.orglett.6c03239
UR - https://europepmc.org/article/MED/42917824
AB - Cyclic acetals and gem-difluoroalkenes are proven structural motifs in medicinal chemistry, yet their modular incorporation into a densely functionalized hybrid architecture remains an uncharted frontier. Herein, we disclose an Fe-catalyzed reductive defluorinative cross-coupling between trifluoromethyl alkenes and 1,3-dioxolanyl- or 1,3-dioxepanyl-substituted alkyl iodides, enabling the rapid assembly of five- or seven-membered cyclic acetal-embodied fluorinated scaffolds, respectively. This protocol enriches defluorinative coupling versatility and offers streamlined access to structurally diverse pharmaceutically relevant scaffolds.
SN - 1523-7060
SN - 1523-7052
ER -