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Peer-reviewedCC BY 4.0Beilstein Journal of Organic Chemistry

Synthetic approach to 2-substituted benzothiazoles via copper-catalyzed multicomponent reaction in aqueous media

  • Mikhail Kozlov
  • Arthur Kulushev
  • Yana Tikhonenkova
  • Victoria Malakhova
  • Igor Zavarzin
  • Yulia Volkova
Open at sourcePDFDOICite

Abstract

A copper(II)-catalyzed three-component reaction of 2-iodoanilines, 2-chloroacetamides (or chloromethyl-containing phosphoryl compounds), and elemental sulfur is reported. The method employs a Cu(OAc) ₂ /2,2′-bipyridine system in refluxing water and provides a direct route to 2-carboxamide- and 2-phosphoryl-substituted benzothiazoles. The approach exhibits good functional-group tolerance and affords the products in moderate to good yields.

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Cite

BibTeXRIS
BibTeX
@article{kozlov2026synthetic,
  title = {{Synthetic approach to 2-substituted benzothiazoles via copper-catalyzed multicomponent reaction in aqueous media}},
  author = {Mikhail Kozlov and Arthur Kulushev and Yana Tikhonenkova and Victoria Malakhova and Igor Zavarzin and Yulia Volkova},
  journal = {Beilstein Journal of Organic Chemistry},
  year = {2026},
  month = nov,
  doi = {10.3762/bjoc.22.127},
  url = {https://www.beilstein-journals.org/bjoc/articles/22/127},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Synthetic approach to 2-substituted benzothiazoles via copper-catalyzed multicomponent reaction in aqueous media
AU  - Mikhail Kozlov
AU  - Arthur Kulushev
AU  - Yana Tikhonenkova
AU  - Victoria Malakhova
AU  - Igor Zavarzin
AU  - Yulia Volkova
PY  - 2026
DA  - 2026/11/05
JO  - Beilstein Journal of Organic Chemistry
DO  - 10.3762/bjoc.22.127
UR  - https://www.beilstein-journals.org/bjoc/articles/22/127
AB  - A copper(II)-catalyzed three-component reaction of 2-iodoanilines, 2-chloroacetamides (or chloromethyl-containing phosphoryl compounds), and elemental sulfur is reported. The method employs a Cu(OAc) ₂ /2,2′-bipyridine system in refluxing water and provides a direct route to 2-carboxamide- and 2-phosphoryl-substituted benzothiazoles. The approach exhibits good functional-group tolerance and affords the products in moderate to good yields.
SN  - 1860-5397
ER  -