Chemical composition, oral acute toxicity and anti-inflammatory activity of Thymus hirtus Willd. essential oil.
Abstract
This study aimed to determine the chemical composition of Thymus hirtus essential oil and to assess its acute toxicity and anti-inflammatory potential. This essential oil extracted by hydrodistillation from the leaves has a yield of 2.08 ± 0.5 %. The identification of its chemical composition was conducted using both GC-FID and GC-MS. Fifty-four constituents were detected, representing 98.53 % of the essential oil's composition. The major constituents were : thymol (48.5 %) and carvacrol (17.75 %). The oral acute toxicity of this essential oil was evaluated in mice by administering single doses ranging from 50 to 2000 mg/kg. The lethal dose (LD50) obtained was equal to 875 mg/kg. The anti-inflammatory activity was assessed using carrageenan-induced paw edema test in mice. A notable reduction of paw edema was obtained at dose of 50 mg/kg (50.9 %) and 100 mg/kg (65.6 %). The reported anti-inflammatory activity represents a significant initial outcome, underscoring the relevance of this work and paving the way for future investigations to validate and extend these findings.
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BibTeX
@article{touaibia2026chemical,
title = {{Chemical composition, oral acute toxicity and anti-inflammatory activity of Thymus hirtus Willd. essential oil.}},
author = {Meriem TOUAIBIA},
journal = {Journal of Oleo Science},
year = {2026},
month = aug,
doi = {10.5650/jos.ess25191},
url = {https://www.jstage.jst.go.jp/article/jos/75/8/75_jos.ess25191/_article},
note = {CC BY},
}
RIS
TY - JOUR
TI - Chemical composition, oral acute toxicity and anti-inflammatory activity of Thymus hirtus Willd. essential oil.
AU - Meriem TOUAIBIA
PY - 2026
DA - 2026/08/01
JO - Journal of Oleo Science
DO - 10.5650/jos.ess25191
UR - https://www.jstage.jst.go.jp/article/jos/75/8/75_jos.ess25191/_article
AB - This study aimed to determine the chemical composition of Thymus hirtus essential oil and to assess its acute toxicity and anti-inflammatory potential. This essential oil extracted by hydrodistillation from the leaves has a yield of 2.08 ± 0.5 %. The identification of its chemical composition was conducted using both GC-FID and GC-MS. Fifty-four constituents were detected, representing 98.53 % of the essential oil's composition. The major constituents were : thymol (48.5 %) and carvacrol (17.75 %). The oral acute toxicity of this essential oil was evaluated in mice by administering single doses ranging from 50 to 2000 mg/kg. The lethal dose (LD50) obtained was equal to 875 mg/kg. The anti-inflammatory activity was assessed using carrageenan-induced paw edema test in mice. A notable reduction of paw edema was obtained at dose of 50 mg/kg (50.9 %) and 100 mg/kg (65.6 %). The reported anti-inflammatory activity represents a significant initial outcome, underscoring the relevance of this work and paving the way for future investigations to validate and extend these findings.
SN - 1347-3352
SN - 1345-8957
ER -