Chemical Composition and Multiple Bioactivities of Ageratum conyzoides Essential Oil Collected in Dak Lak, Vietnam
Abstract
The essential oil of Ageratum conyzoides collected from Dak Lak Province, Vietnam, was investigated for its chemical composition and biological activities. Gas chromatography-mass spectrometry (GC-MS) analysis identified 26 volatile constituents, accounting for 78.8 % of the total oil content, predominantly composed of monoterpenoids (60.6 %) and sesquiterpenoids (18.2 %). The major components included caryophyllene (15.57 %), sabinene (14.78 %), isomyocorene (3.62 %), eucalyptol (12.46 %), humulene (8.91 %), nerolidol (5.80 %), α-pinene (3.09 %), and 3-carene (3.05 %). The essential oil exhibited notable antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay with an IC50 value of 6.03 ± 0.4 mg/mL. In addition, moderate antibacterial activity against Escherichia coli was observed, with an inhibition zone diameter of 27.0 mm at 3.00 mg/mL and a minimum inhibitory concentration of 100 µg/mL. The oil also demonstrated moderate α-glucosidase inhibitory activity with an IC50 value of 415.4 μg/mL. Molecular docking analysis provided only preliminary and hypothesis-generating insights, suggesting that major constituents such as caryophyllene and nerolidol may be associated with the observed activities. However, these in silico results do not provide direct evidence of DNA GyrB or α-glucosidase inhibition by individual compounds. These findings indicate that A. conyzoides essential oil represents a potential natural source of multifunctional bioactive compounds for further pharmacological investigation.
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BibTeX
@article{nguyen2026chemical,
title = {{Chemical Composition and Multiple Bioactivities of Ageratum conyzoides Essential Oil Collected in Dak Lak, Vietnam}},
author = {Thi Kim An Nguyen and Manh Ha Nguyen and Truong Nhan Ngu and Thi Bich Hanh Dam and Phuong Dai Nguyen Nguyen and Minh Quan Pham and Phi Hung Nguyen and Thi Thuy Do and Viet Tuan Trinh and Tien Khi Nguyen and Dao Cuong To},
journal = {Journal of Oleo Science},
year = {2026},
month = aug,
doi = {10.5650/jos.ess26040},
url = {https://www.jstage.jst.go.jp/article/jos/75/8/75_jos.ess26040/_article},
note = {CC BY},
}
RIS
TY - JOUR
TI - Chemical Composition and Multiple Bioactivities of Ageratum conyzoides Essential Oil Collected in Dak Lak, Vietnam
AU - Thi Kim An Nguyen
AU - Manh Ha Nguyen
AU - Truong Nhan Ngu
AU - Thi Bich Hanh Dam
AU - Phuong Dai Nguyen Nguyen
AU - Minh Quan Pham
AU - Phi Hung Nguyen
AU - Thi Thuy Do
AU - Viet Tuan Trinh
AU - Tien Khi Nguyen
AU - Dao Cuong To
PY - 2026
DA - 2026/08/01
JO - Journal of Oleo Science
DO - 10.5650/jos.ess26040
UR - https://www.jstage.jst.go.jp/article/jos/75/8/75_jos.ess26040/_article
AB - The essential oil of Ageratum conyzoides collected from Dak Lak Province, Vietnam, was investigated for its chemical composition and biological activities. Gas chromatography-mass spectrometry (GC-MS) analysis identified 26 volatile constituents, accounting for 78.8 % of the total oil content, predominantly composed of monoterpenoids (60.6 %) and sesquiterpenoids (18.2 %). The major components included caryophyllene (15.57 %), sabinene (14.78 %), isomyocorene (3.62 %), eucalyptol (12.46 %), humulene (8.91 %), nerolidol (5.80 %), α-pinene (3.09 %), and 3-carene (3.05 %). The essential oil exhibited notable antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay with an IC50 value of 6.03 ± 0.4 mg/mL. In addition, moderate antibacterial activity against Escherichia coli was observed, with an inhibition zone diameter of 27.0 mm at 3.00 mg/mL and a minimum inhibitory concentration of 100 µg/mL. The oil also demonstrated moderate α-glucosidase inhibitory activity with an IC50 value of 415.4 μg/mL. Molecular docking analysis provided only preliminary and hypothesis-generating insights, suggesting that major constituents such as caryophyllene and nerolidol may be associated with the observed activities. However, these in silico results do not provide direct evidence of DNA GyrB or α-glucosidase inhibition by individual compounds. These findings indicate that A. conyzoides essential oil represents a potential natural source of multifunctional bioactive compounds for further pharmacological investigation.
SN - 1347-3352
SN - 1345-8957
ER -