Peer-reviewedCC BY-NCChemical and Pharmaceutical Bulletin
Structural Characterization of New 8,17-Epoxybriarane Diterpenoids from the Octocoral Briareum stechei
Abstract
An encrusting, algae-associated octocoral, Briareum stechei, afforded three 8,17-epoxybriarane diterpenoids, including the known compound briaexcavatolide B (1) and two previously undescribed analogues, briastecholides Q (2) and R (3). The absolute configuration of 1 was established for the first time by single-crystal X-ray diffraction analysis. The planar structures and relative configurations of 2 and 3 were determined through extensive spectroscopic analyses. In bioactivity evaluation, compound 2 exhibited cytotoxic effects toward the human acute lymphoblastic leukemia cell lines Molt-4 and CCRF-CEM.
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BibTeX
@article{liu2026structural,
title = {{Structural Characterization of New 8,17-Epoxybriarane Diterpenoids from the Octocoral Briareum stechei}},
author = {Yuan-Hao Liu and Chih-Kai Hsu and Liu-Guo Zheng and Su-Ying Chien and Yu-Jen Wu and Jih-Jung Chen and Mingzi M. Zhang and Zhi-Hong Wen and Yuan-Bin Cheng and Lun Kelvin Tsou and Mei-Chin Lu and Jyh-Horng Sheu and Shih-Hsiung Lin and Ping-Jyun Sung},
journal = {Chemical and Pharmaceutical Bulletin},
year = {2026},
month = aug,
doi = {10.1248/cpb.c26-00274},
url = {https://www.jstage.jst.go.jp/article/cpb/74/8/74_c26-00274/_article},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Structural Characterization of New 8,17-Epoxybriarane Diterpenoids from the Octocoral Briareum stechei
AU - Yuan-Hao Liu
AU - Chih-Kai Hsu
AU - Liu-Guo Zheng
AU - Su-Ying Chien
AU - Yu-Jen Wu
AU - Jih-Jung Chen
AU - Mingzi M. Zhang
AU - Zhi-Hong Wen
AU - Yuan-Bin Cheng
AU - Lun Kelvin Tsou
AU - Mei-Chin Lu
AU - Jyh-Horng Sheu
AU - Shih-Hsiung Lin
AU - Ping-Jyun Sung
PY - 2026
DA - 2026/08/04
JO - Chemical and Pharmaceutical Bulletin
DO - 10.1248/cpb.c26-00274
UR - https://www.jstage.jst.go.jp/article/cpb/74/8/74_c26-00274/_article
AB - An encrusting, algae-associated octocoral, Briareum stechei, afforded three 8,17-epoxybriarane diterpenoids, including the known compound briaexcavatolide B (1) and two previously undescribed analogues, briastecholides Q (2) and R (3). The absolute configuration of 1 was established for the first time by single-crystal X-ray diffraction analysis. The planar structures and relative configurations of 2 and 3 were determined through extensive spectroscopic analyses. In bioactivity evaluation, compound 2 exhibited cytotoxic effects toward the human acute lymphoblastic leukemia cell lines Molt-4 and CCRF-CEM.
SN - 1347-5223
SN - 0009-2363
ER -