A Single Smart Nanomaterial for Near-Infrared-Switchable Theranostics of Hemorrhage and Thrombosis via Photoacoustic Imaging.
7 affiliations
- 1Emergency Department of the Affiliated Hospital/College of Clinical Medicine Guizhou Medical University Guiyang Guizhou P. R. China.
- 2State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Natural Products Research Center of Guizhou Province Guizhou Medical University Guiyang P. R. China.
- 3Department of Emergency The First Affiliated Hospital Hengyang Medical School University of South China Hengyang Hunan P. R. China.
- 4State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian P. R. China.
- 5Department of Radiology Xinqiao Hospital Army Medical University Chongqing P. R. China.
- 6College of Basic Medical Guizhou Medical University Guiyang Guizhou P. R. China.
- 7College of Optoelectronic Engineering Chongqing University of Posts and Telecommunications Chongqing P. R. China.
Abstract
The clinical management of hemorrhagic patients remains a significant challenge, as current therapeutic approaches lack real-time diagnostic capability and spatiotemporal precision. Conventional materials (e.g., hydrogels) require surgical intervention, while molecular targeting strategies are limited by slow kinetics and uncontrollable thrombotic risks. To address these limitations, we developed a smart nanomaterial based on a NiFe-layered double hydroxide decorated with both Ag single atoms and nanoparticles (AgSA + NP/NiFe-LDH). This platform can bind plasminogen activators, achieving rapid hemostasis with approximately 30% reduced fibrinolysis in vitro and approximately 50% reduced blood loss in vivo in models of intracranial and abdominal hemorrhage. Under pulsed near-infrared (NIR) irradiation, the dominant photoelectric effect enhances hemostatic efficacy, reducing blood loss by about 50% compared to the unexposed part; under sustained NIR exposure, strong photothermal effects inactivate clot-enriched thrombin and alter fibrin structure, thereby promoting controlled thrombolysis. This dual functionality is consistently demonstrated in arterial models and in cryopreserved human blood samples from healthy individuals and hemorrhagic patients. Moreover, the material enables real-time visualization of active bleeding (as low as 3 μL) via photoacoustic imaging, as validated in an intracranial hemorrhage model. Our work demonstrates a proof-of-concept NIR-based strategy for externally modulated management with potential applications in dynamic vascular emergencies.
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BibTeX
@article{ye2026single,
title = {{A Single Smart Nanomaterial for Near-Infrared-Switchable Theranostics of Hemorrhage and Thrombosis via Photoacoustic Imaging.}},
author = {Yi Ye and Zhilu Sun and Daofu Wu and Jun'an Lai and Mingyue Yang and Zhiqiong Luo and Sha Cheng and Suwen Yang and Hong Zeng and Yinghui Li and Faguang Kuang and Baofei Sun and Wenxia Zhang and Xiaosheng Tang and Heng Luo and Guofeng Wu},
journal = {Small science},
year = {2026},
month = nov,
doi = {10.1002/smsc.70366},
url = {https://europepmc.org/article/MED/42996816},
note = {CC BY},
}
RIS
TY - JOUR
TI - A Single Smart Nanomaterial for Near-Infrared-Switchable Theranostics of Hemorrhage and Thrombosis via Photoacoustic Imaging.
AU - Yi Ye
AU - Zhilu Sun
AU - Daofu Wu
AU - Jun'an Lai
AU - Mingyue Yang
AU - Zhiqiong Luo
AU - Sha Cheng
AU - Suwen Yang
AU - Hong Zeng
AU - Yinghui Li
AU - Faguang Kuang
AU - Baofei Sun
AU - Wenxia Zhang
AU - Xiaosheng Tang
AU - Heng Luo
AU - Guofeng Wu
PY - 2026
DA - 2026/11/05
JO - Small science
DO - 10.1002/smsc.70366
UR - https://europepmc.org/article/MED/42996816
AB - The clinical management of hemorrhagic patients remains a significant challenge, as current therapeutic approaches lack real-time diagnostic capability and spatiotemporal precision. Conventional materials (e.g., hydrogels) require surgical intervention, while molecular targeting strategies are limited by slow kinetics and uncontrollable thrombotic risks. To address these limitations, we developed a smart nanomaterial based on a NiFe-layered double hydroxide decorated with both Ag single atoms and nanoparticles (AgSA + NP/NiFe-LDH). This platform can bind plasminogen activators, achieving rapid hemostasis with approximately 30% reduced fibrinolysis in vitro and approximately 50% reduced blood loss in vivo in models of intracranial and abdominal hemorrhage. Under pulsed near-infrared (NIR) irradiation, the dominant photoelectric effect enhances hemostatic efficacy, reducing blood loss by about 50% compared to the unexposed part; under sustained NIR exposure, strong photothermal effects inactivate clot-enriched thrombin and alter fibrin structure, thereby promoting controlled thrombolysis. This dual functionality is consistently demonstrated in arterial models and in cryopreserved human blood samples from healthy individuals and hemorrhagic patients. Moreover, the material enables real-time visualization of active bleeding (as low as 3 μL) via photoacoustic imaging, as validated in an intracranial hemorrhage model. Our work demonstrates a proof-of-concept NIR-based strategy for externally modulated management with potential applications in dynamic vascular emergencies.
SN - 2688-4046
ER -