Long-chain Omega-3 fatty acids supplementation and cognitive performance throughout adulthood: A 6-month randomized controlled trial.
Abstract
OBJECTIVE: To investigate whether omega-3 polyunsaturated fatty acids (n-3 PUFA) supplementation improve cognitive performance and if apolipoprotein E (APOE) genotype or age were effect modifiers. METHODS: Healthy adults of 20 to 80 years old (n = 193) were completed a 6-month double-blind randomized controlled trial with two groups: 2.5 g/day of n-3 PUFA or a placebo. Primary outcomes were visuospatial ability and working memory and secondary outcomes were episodic memory and executive function, measured at baseline and 6 months. RESULTS: Cognitive performances did not significantly differ between groups on primary or secondary outcomes after 6 months of treatment. APOE carriers and age were not effect modifiers for any outcomes. Those with low episodic memory scores and taking the n-3 PUFA supplement, significantly improved their scores (p = 0.043). CONCLUSIONS: A 6-month n-3 PUFA supplementation did not improve cognitive performance in cognitively healthy adults and APOE status or age were not effect modifiers.
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BibTeX
@article{maltais2026longchain,
title = {{Long-chain Omega-3 fatty acids supplementation and cognitive performance throughout adulthood: A 6-month randomized controlled trial.}},
author = {Mathieu Maltais and Dominique Lorrain and Pauline Léveillé and Isabelle Viens and Annick Vachon and Anita Houeto and Nancy Presse and Mélanie Plourde},
journal = {Prostaglandins, Leukotrienes and Essential Fatty Acids},
year = {2026},
month = oct,
doi = {10.1016/j.plefa.2022.102415},
url = {https://hal.science/hal-05790370v1},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Long-chain Omega-3 fatty acids supplementation and cognitive performance throughout adulthood: A 6-month randomized controlled trial.
AU - Mathieu Maltais
AU - Dominique Lorrain
AU - Pauline Léveillé
AU - Isabelle Viens
AU - Annick Vachon
AU - Anita Houeto
AU - Nancy Presse
AU - Mélanie Plourde
PY - 2026
DA - 2026/10/09
JO - Prostaglandins, Leukotrienes and Essential Fatty Acids
DO - 10.1016/j.plefa.2022.102415
UR - https://hal.science/hal-05790370v1
AB - OBJECTIVE: To investigate whether omega-3 polyunsaturated fatty acids (n-3 PUFA) supplementation improve cognitive performance and if apolipoprotein E (APOE) genotype or age were effect modifiers. METHODS: Healthy adults of 20 to 80 years old (n = 193) were completed a 6-month double-blind randomized controlled trial with two groups: 2.5 g/day of n-3 PUFA or a placebo. Primary outcomes were visuospatial ability and working memory and secondary outcomes were episodic memory and executive function, measured at baseline and 6 months. RESULTS: Cognitive performances did not significantly differ between groups on primary or secondary outcomes after 6 months of treatment. APOE carriers and age were not effect modifiers for any outcomes. Those with low episodic memory scores and taking the n-3 PUFA supplement, significantly improved their scores (p = 0.043). CONCLUSIONS: A 6-month n-3 PUFA supplementation did not improve cognitive performance in cognitively healthy adults and APOE status or age were not effect modifiers.
SN - 0952-3278
ER -