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Peer-reviewedCC BYVirulence

The long noncoding RNA MAPKAPK5-AS1 promotes the formation of hepatitis B virus cccDNA by modulating the expression of NABP1.

  • Xiaolu Zhang1,2
  • Tingting Liu3
  • Qiuyue Jiang1,2
  • Zhijie Hu1,2
  • Shan Cen4
  • Quan Zhang2
4 affiliations
  1. 1Joint Institute of Nanjing Drum Tower Hospital for Life and Health, College of Life Science, Nanjing Normal University, Jiangsu, China.
  2. 2Department of Laboratory Medicine, Nanjing Drum Tower Hospital and Jiangsu Key Laboratory for Molecular Medicine, The Affiliated Hospital of Nanjing University Medical School, Jiangsu, China.
  3. 3Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Jiangsu, China.
  4. 4Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China.
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Abstract

Cellular long noncoding RNAs (lncRNAs) have been shown to participate in diverse biological pathways, including the regulation of virus infections. However, their functions in the hepatitis B virus (HBV) life cycle still need to be explored. Here, we conducted a loss-of-function screen targeting 1779 human lncRNAs and identified 19 lncRNAs associated with HBV infection. One lncRNA, named MAPKAPK5-AS1 (lnc-MAAS), was identified as a host factor required for HBV infection. Our data suggest that lnc-MAAS is involved in the conversion of HBV relaxed circular DNA into covalently closed circular DNA (cccDNA). Furthermore, mechanistic experiments revealed that lnc-MAAS affects cccDNA formation by modulating the expression of nucleic acid binding protein 1 (NABP1). Together, our findings shed light on the roles of host lnc-MAAS and NABP1 in HBV cccDNA formation, which may contribute to the development of novel anti-HBV therapeutics.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026long,
  title = {{The long noncoding RNA MAPKAPK5-AS1 promotes the formation of hepatitis B virus cccDNA by modulating the expression of NABP1.}},
  author = {Xiaolu Zhang and Tingting Liu and Qiuyue Jiang and Zhijie Hu and Shan Cen and Quan Zhang},
  journal = {Virulence},
  year = {2026},
  month = oct,
  doi = {10.1080/21505594.2026.2745300},
  url = {https://europepmc.org/article/MED/42864869},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The long noncoding RNA MAPKAPK5-AS1 promotes the formation of hepatitis B virus cccDNA by modulating the expression of NABP1.
AU  - Xiaolu Zhang
AU  - Tingting Liu
AU  - Qiuyue Jiang
AU  - Zhijie Hu
AU  - Shan Cen
AU  - Quan Zhang
PY  - 2026
DA  - 2026/10/12
JO  - Virulence
DO  - 10.1080/21505594.2026.2745300
UR  - https://europepmc.org/article/MED/42864869
AB  - Cellular long noncoding RNAs (lncRNAs) have been shown to participate in diverse biological pathways, including the regulation of virus infections. However, their functions in the hepatitis B virus (HBV) life cycle still need to be explored. Here, we conducted a loss-of-function screen targeting 1779 human lncRNAs and identified 19 lncRNAs associated with HBV infection. One lncRNA, named MAPKAPK5-AS1 (lnc-MAAS), was identified as a host factor required for HBV infection. Our data suggest that lnc-MAAS is involved in the conversion of HBV relaxed circular DNA into covalently closed circular DNA (cccDNA). Furthermore, mechanistic experiments revealed that lnc-MAAS affects cccDNA formation by modulating the expression of nucleic acid binding protein 1 (NABP1). Together, our findings shed light on the roles of host lnc-MAAS and NABP1 in HBV cccDNA formation, which may contribute to the development of novel anti-HBV therapeutics.
SN  - 2150-5594
SN  - 2150-5608
ER  -