Biotechnological Potential of Biosurfactant-Based Ointment: A Promising Biomaterial for Enhanced Wounds Healing
Abstract
This study evaluated and compared the wound-healing effects of biosurfactant-loaded ointments derived from the viscera of Catla catla fish at concentrations of 25, 50, and 75 µg/mL. The results demonstrated significant improvements in wound contraction and tissue regeneration. The greater wound contraction (84.31 ± 1.7 %) was observed in the group treated with the 75 µg/mL ointment group on day 10, showing a significant difference from the negative control (69.68 ± 1.3 %) (p ≤ 0.05). Histological analysis revealed re-epithelization and hair follicle formation in the 75 µg/mL ointment group, indicating complete tissue regeneration. To further confirm the efficacy of ointments, antioxidant assays were performed. On day 10, the 75 µg/mL ointment group showed a significantly higher glutathione level (GSH) (51.3 ± 2.8 mg/L) than the negative control group (20.9 ± 0.8 mg/L, p < 0.01). Additionally, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were significantly higher in the 50 µg/mL ointment group than in the control group, with values of 208.0 ± 3.3 U/mL for SOD and 207.4 ± 4.0 U/L for GSH-Px (p < 0.01), respectively. These findings suggest that biosurfactant ointments enhance wound healing by promoting wound contraction, strengthening antioxidant defense, and supporting tissue regeneration, highlighting their potential as effective alternative to conventional wound treatments.
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BibTeX
@article{jurrat2026biotechnological,
title = {{Biotechnological Potential of Biosurfactant-Based Ointment: A Promising Biomaterial for Enhanced Wounds Healing}},
author = {Husna Jurrat and Iram Liaqat and Sajida Naseem and Fakhar-un-Nisa Yunus and Saiqa Andleeb and Gulbeena Saleem and Abid Ali and Muhammad Nauman Aftab and Sikander Ali and Nawal Alsubaie},
journal = {Journal of Oleo Science},
year = {2026},
month = sep,
doi = {10.5650/jos.ess26029},
url = {https://www.jstage.jst.go.jp/article/jos/75/9/75_jos.ess26029/_article},
note = {CC BY},
}
RIS
TY - JOUR
TI - Biotechnological Potential of Biosurfactant-Based Ointment: A Promising Biomaterial for Enhanced Wounds Healing
AU - Husna Jurrat
AU - Iram Liaqat
AU - Sajida Naseem
AU - Fakhar-un-Nisa Yunus
AU - Saiqa Andleeb
AU - Gulbeena Saleem
AU - Abid Ali
AU - Muhammad Nauman Aftab
AU - Sikander Ali
AU - Nawal Alsubaie
PY - 2026
DA - 2026/09/01
JO - Journal of Oleo Science
DO - 10.5650/jos.ess26029
UR - https://www.jstage.jst.go.jp/article/jos/75/9/75_jos.ess26029/_article
AB - This study evaluated and compared the wound-healing effects of biosurfactant-loaded ointments derived from the viscera of Catla catla fish at concentrations of 25, 50, and 75 µg/mL. The results demonstrated significant improvements in wound contraction and tissue regeneration. The greater wound contraction (84.31 ± 1.7 %) was observed in the group treated with the 75 µg/mL ointment group on day 10, showing a significant difference from the negative control (69.68 ± 1.3 %) (p ≤ 0.05). Histological analysis revealed re-epithelization and hair follicle formation in the 75 µg/mL ointment group, indicating complete tissue regeneration. To further confirm the efficacy of ointments, antioxidant assays were performed. On day 10, the 75 µg/mL ointment group showed a significantly higher glutathione level (GSH) (51.3 ± 2.8 mg/L) than the negative control group (20.9 ± 0.8 mg/L, p < 0.01). Additionally, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were significantly higher in the 50 µg/mL ointment group than in the control group, with values of 208.0 ± 3.3 U/mL for SOD and 207.4 ± 4.0 U/L for GSH-Px (p < 0.01), respectively. These findings suggest that biosurfactant ointments enhance wound healing by promoting wound contraction, strengthening antioxidant defense, and supporting tissue regeneration, highlighting their potential as effective alternative to conventional wound treatments.
SN - 1347-3352
SN - 1345-8957
ER -