Temperature/pH Dual-Responsive Hydrogels: Research Progress in Preparation Methods, Structural Design Strategies and Biomedical Applications
- 1School of Physics and Electronic Science, Guizhou Normal University, Guiyang 550025, China
- 2School of Integrated Circuit, Guizhou Normal University, Guiyang 550025, China
Abstract
Temperature/pH dual-responsive hydrogels are a class of smart materials capable of undergoing reversible structural or functional changes in response to temperature and pH stimuli. Owing to their remarkable dual-stimuli-responsive characteristics, these hydrogels have demonstrated significant potential in various biomedical applications, including drug delivery, tissue engineering, and diagnostics technologies, making them a prominent research focus. Although considerable progress has been made in recent years, a systematic summary of the preparation methods, structural design strategies and complex biomedical applications of these materials remains conspicuously absent. Consequently, this review aims to comprehensively examine the latest advancements in this field. First, the primary preparation methods of temperature/pH dual-responsive hydrogels, including chemical crosslinking, physical crosslinking, and hybrid crosslinking, are introduced and compared. Subsequently, the main structural design strategies, including microsphere, core-shell and layered structures, and their corresponding fabrication processes are systematically elucidated. Finally, the recent progress of temperature/pH dual-responsive hydrogels in biomedical applications is discussed, including drug delivery, cancer therapy, biosensing and diagnosis, tissue engineering and regenerative medicine, as well as wound healing. Based on the current research progress, this review also outlines the major challenges in the development of temperature/pH dual-responsive hydrogels, and presents perspectives on future research directions.
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BibTeX
@article{wang2026temperatureph,
title = {{Temperature/pH Dual-Responsive Hydrogels: Research Progress in Preparation Methods, Structural Design Strategies and Biomedical Applications}},
author = {Sisi Wang and Gang Wang and Xuefei Liu and Jinshun Bi and Wenjun Xiao and Degui Wang and Mingqiang Liu and Changsong Gao and Ziqiang Xu and Zhen Wang and Yan Wu and Abuduwayiti Aierken},
journal = {Gels},
year = {2026},
month = may,
doi = {10.3390/gels12050433},
url = {https://doi.org/10.3390/gels12050433},
note = {CC BY},
}
RIS
TY - JOUR
TI - Temperature/pH Dual-Responsive Hydrogels: Research Progress in Preparation Methods, Structural Design Strategies and Biomedical Applications
AU - Sisi Wang
AU - Gang Wang
AU - Xuefei Liu
AU - Jinshun Bi
AU - Wenjun Xiao
AU - Degui Wang
AU - Mingqiang Liu
AU - Changsong Gao
AU - Ziqiang Xu
AU - Zhen Wang
AU - Yan Wu
AU - Abuduwayiti Aierken
PY - 2026
DA - 2026/05/15
JO - Gels
DO - 10.3390/gels12050433
UR - https://doi.org/10.3390/gels12050433
AB - Temperature/pH dual-responsive hydrogels are a class of smart materials capable of undergoing reversible structural or functional changes in response to temperature and pH stimuli. Owing to their remarkable dual-stimuli-responsive characteristics, these hydrogels have demonstrated significant potential in various biomedical applications, including drug delivery, tissue engineering, and diagnostics technologies, making them a prominent research focus. Although considerable progress has been made in recent years, a systematic summary of the preparation methods, structural design strategies and complex biomedical applications of these materials remains conspicuously absent. Consequently, this review aims to comprehensively examine the latest advancements in this field. First, the primary preparation methods of temperature/pH dual-responsive hydrogels, including chemical crosslinking, physical crosslinking, and hybrid crosslinking, are introduced and compared. Subsequently, the main structural design strategies, including microsphere, core-shell and layered structures, and their corresponding fabrication processes are systematically elucidated. Finally, the recent progress of temperature/pH dual-responsive hydrogels in biomedical applications is discussed, including drug delivery, cancer therapy, biosensing and diagnosis, tissue engineering and regenerative medicine, as well as wound healing. Based on the current research progress, this review also outlines the major challenges in the development of temperature/pH dual-responsive hydrogels, and presents perspectives on future research directions.
SN - 2310-2861
ER -