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Peer-reviewedCC BY-NC-NDJID innovations : skin science from molecules to population health

Human papillomavirus E6/7 specific T-cell responses among Asian individuals with cutaneous squamous cell carcinoma.

  • Choon C Oh1,2
  • Christine Tham3
  • Noor Z Hamis2
  • Yan S Leong2
  • Gek H Lim4
  • Eng E Ooi2,5
5 affiliations
  1. 1Department of Dermatology, Singapore General Hospital, Singapore.
  2. 2Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore.
  3. 3Agency for Science, Technology and Research, Singapore.
  4. 4Health Services Research Unit, Singapore General Hospital, Singapore.
  5. 5Department of Clinical Translational Research, Singapore General Hospital, Singapore.
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Abstract

Cutaneous human papillomavirus (HPV)-specific cell-mediated immunity in patients with cutaneous squamous cell carcinoma (SCC) remains poorly understood, particularly in organ transplant recipients (OTRs), who often develop multiple viral warts and SCC under long-term immunosuppression. This study characterized HPV E6/E7-specific T-cell responses in OTRs with SCC and compared them with immunocompetent individuals with SCC. Participants were recruited in Singapore and included OTRs with a history of posttransplant primary SCC (n = 28) and immunocompetent individuals with SCC (n = 10). Fifteen-mer peptides spanning the E6/E7 regions of HPV8, HPV17, HPV49, and HPV98 were synthesized, and HPV-specific T-cell responses were measured using an enzyme-linked immune absorbent spot assay. Most participants showed positive responses to cytomegalovirus peptide, the positive control, with response rates of 82% in OTRs and 70% in immunocompetent participants. Among OTRs, 28.57% responded to HPV17 E6/E7 peptides and 14.29% to HPV98, while responses to HPV8 and HPV49 were lower (7.14% and 3.57%, respectively). In immunocompetent participants, 20% responded to HPV17 and HPV49, 10% to HPV8, and none to HPV98. This study provides preliminary evidence that circulating T cells reactive to selected β-HPV E6/E7 peptide pools can be detected in a subset of Asian participants with cutaneous SCC, including OTRs.

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Cite

BibTeXRIS
BibTeX
@article{oh2026human,
  title = {{Human papillomavirus E6/7 specific T-cell responses among Asian individuals with cutaneous squamous cell carcinoma.}},
  author = {Choon C Oh and Christine Tham and Noor Z Hamis and Yan S Leong and Gek H Lim and Eng E Ooi},
  journal = {JID innovations : skin science from molecules to population health},
  year = {2026},
  month = aug,
  doi = {10.1016/j.xjidi.2026.100526},
  url = {https://europepmc.org/article/MED/42927223},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Human papillomavirus E6/7 specific T-cell responses among Asian individuals with cutaneous squamous cell carcinoma.
AU  - Choon C Oh
AU  - Christine Tham
AU  - Noor Z Hamis
AU  - Yan S Leong
AU  - Gek H Lim
AU  - Eng E Ooi
PY  - 2026
DA  - 2026/08/13
JO  - JID innovations : skin science from molecules to population health
DO  - 10.1016/j.xjidi.2026.100526
UR  - https://europepmc.org/article/MED/42927223
AB  - Cutaneous human papillomavirus (HPV)-specific cell-mediated immunity in patients with cutaneous squamous cell carcinoma (SCC) remains poorly understood, particularly in organ transplant recipients (OTRs), who often develop multiple viral warts and SCC under long-term immunosuppression. This study characterized HPV E6/E7-specific T-cell responses in OTRs with SCC and compared them with immunocompetent individuals with SCC. Participants were recruited in Singapore and included OTRs with a history of posttransplant primary SCC (n = 28) and immunocompetent individuals with SCC (n = 10). Fifteen-mer peptides spanning the E6/E7 regions of HPV8, HPV17, HPV49, and HPV98 were synthesized, and HPV-specific T-cell responses were measured using an enzyme-linked immune absorbent spot assay. Most participants showed positive responses to cytomegalovirus peptide, the positive control, with response rates of 82% in OTRs and 70% in immunocompetent participants. Among OTRs, 28.57% responded to HPV17 E6/E7 peptides and 14.29% to HPV98, while responses to HPV8 and HPV49 were lower (7.14% and 3.57%, respectively). In immunocompetent participants, 20% responded to HPV17 and HPV49, 10% to HPV8, and none to HPV98. This study provides preliminary evidence that circulating T cells reactive to selected β-HPV E6/E7 peptide pools can be detected in a subset of Asian participants with cutaneous SCC, including OTRs.
SN  - 2667-0267
ER  -