Angiogenesis in temporomandibular joint osteoarthritis: an update on mechanisms and research advances.
- 1Guizhou University of Traditional Chinese Medicine, Gui Yang, China.
Abstract
Temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative disorder characterized by condylar cartilage degeneration, abnormal subchondral bone remodeling, and synovial inflammation. Its pathogenesis is complex, and effective clinical interventions remain limited. In recent years, the critical role of angiogenesis in TMJOA pathogenesis has garnered increasing attention. During TMJOA progression, angiogenesis interacts dynamically with bone metabolism, playing a key role in the imbalance of subchondral bone remodeling, amplification of synovial inflammation, and acceleration of cartilage degradation. Understanding the specific mechanisms of angiogenesis in TMJOA is of great significance for developing novel therapeutic strategies. This article systematically reviews the core regulatory network of angiogenesis in the pathological mechanisms of TMJOA and prospects future research directions, aiming to provide a theoretical basis for mechanistic studies and clinical translation in TMJOA.
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BibTeX
@article{lai2026angiogenesis,
title = {{Angiogenesis in temporomandibular joint osteoarthritis: an update on mechanisms and research advances.}},
author = {Lingyan Lai and Huaiquan Liu and Haiyang Kou and Shili Yang and Xinyan Zhang and Yunlin Xu and Yu Sun and Bo Chen},
journal = {Frontiers in medicine},
year = {2026},
month = oct,
doi = {10.3389/fmed.2026.1866187},
url = {https://europepmc.org/article/MED/42903359},
note = {CC BY},
}
RIS
TY - JOUR
TI - Angiogenesis in temporomandibular joint osteoarthritis: an update on mechanisms and research advances.
AU - Lingyan Lai
AU - Huaiquan Liu
AU - Haiyang Kou
AU - Shili Yang
AU - Xinyan Zhang
AU - Yunlin Xu
AU - Yu Sun
AU - Bo Chen
PY - 2026
DA - 2026/10/06
JO - Frontiers in medicine
DO - 10.3389/fmed.2026.1866187
UR - https://europepmc.org/article/MED/42903359
AB - Temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative disorder characterized by condylar cartilage degeneration, abnormal subchondral bone remodeling, and synovial inflammation. Its pathogenesis is complex, and effective clinical interventions remain limited. In recent years, the critical role of angiogenesis in TMJOA pathogenesis has garnered increasing attention. During TMJOA progression, angiogenesis interacts dynamically with bone metabolism, playing a key role in the imbalance of subchondral bone remodeling, amplification of synovial inflammation, and acceleration of cartilage degradation. Understanding the specific mechanisms of angiogenesis in TMJOA is of great significance for developing novel therapeutic strategies. This article systematically reviews the core regulatory network of angiogenesis in the pathological mechanisms of TMJOA and prospects future research directions, aiming to provide a theoretical basis for mechanistic studies and clinical translation in TMJOA.
SN - 2296-858X
ER -