3D Passive Cavitation Mapping (3D-PCM) with a Large-aperture Planar Array
Abstract
Urinary stone disease is a common urological condition with increasing incidence, particularly in developed countries. Laser lithotripsy (LL) has become a preferred minimally invasive treatment due to its high precision and low tissue damage. Recent studies suggest that cavitation plays a critical role in stone damage during LL, and three-dimensional passive cavitation mapping (3D-PCM) has emerged as a promising tool for detecting these events. However, clinical translation of 3D-PCM remains challenging due to limitations in imaging depth, field of view (FOV), and procedural compatibility. Here, we present a large-FOV dual-modality imaging system (3D-PCM and B-mode ultrasound) based on a large-aperture planar ultrasound array. Through array optimization and model-based reconstruction, our system achieves an expanded FOV of ~ 40 × 40 mm² at a clinically relevant imaging depth of ~ 110 mm, while maintaining high spatial resolution of ~ 0.6 mm laterally and ~ 0.4 mm axially. In vivo experiments in a porcine model demonstrate that the reconstructed cavitation distribution correlates well with stone damage. Our technology has the potential to provide real-time treatment feedback during LL without disrupting the standard workflow.
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BibTeX
@misc{qiu2026passive,
title = {{3D Passive Cavitation Mapping (3D-PCM) with a Large-aperture Planar Array}},
author = {Chaorui Qiu and Daiwei Li and Haoming Huo and Arpit Mishra and Chenhang Li and Kaiping Yin and Nanchao Wang and Junqin Chen and Rui Yao and Ezra J Margolin and Michael Lipkin and Pei Zhong and Xiaoyue Ni and Junjie Yao},
howpublished = {Research Square},
year = {2026},
month = oct,
doi = {10.21203/rs.3.rs-11022521/v1},
url = {https://doi.org/10.21203/rs.3.rs-11022521/v1},
note = {CC BY 4.0},
}
RIS
TY - UNPB
TI - 3D Passive Cavitation Mapping (3D-PCM) with a Large-aperture Planar Array
AU - Chaorui Qiu
AU - Daiwei Li
AU - Haoming Huo
AU - Arpit Mishra
AU - Chenhang Li
AU - Kaiping Yin
AU - Nanchao Wang
AU - Junqin Chen
AU - Rui Yao
AU - Ezra J Margolin
AU - Michael Lipkin
AU - Pei Zhong
AU - Xiaoyue Ni
AU - Junjie Yao
PY - 2026
DA - 2026/10/12
PB - Research Square
DO - 10.21203/rs.3.rs-11022521/v1
UR - https://doi.org/10.21203/rs.3.rs-11022521/v1
AB - Urinary stone disease is a common urological condition with increasing incidence, particularly in developed countries. Laser lithotripsy (LL) has become a preferred minimally invasive treatment due to its high precision and low tissue damage. Recent studies suggest that cavitation plays a critical role in stone damage during LL, and three-dimensional passive cavitation mapping (3D-PCM) has emerged as a promising tool for detecting these events. However, clinical translation of 3D-PCM remains challenging due to limitations in imaging depth, field of view (FOV), and procedural compatibility. Here, we present a large-FOV dual-modality imaging system (3D-PCM and B-mode ultrasound) based on a large-aperture planar ultrasound array. Through array optimization and model-based reconstruction, our system achieves an expanded FOV of ~ 40 × 40 mm² at a clinically relevant imaging depth of ~ 110 mm, while maintaining high spatial resolution of ~ 0.6 mm laterally and ~ 0.4 mm axially. In vivo experiments in a porcine model demonstrate that the reconstructed cavitation distribution correlates well with stone damage. Our technology has the potential to provide real-time treatment feedback during LL without disrupting the standard workflow.
SN - 2693-5015
ER -