Well‐Defined Nickel Precatalysts: Form, Function, and Application
- 1School of Molecular Sciences The University of Western Australia (M310) Crawley WA Australia
Abstract
Modern synthetic methods for the synthesis of pharmaceuticals, fine chemicals, and agrochemicals have been revolutionized by the advent of cross‐coupling chemistry. Well‐defined palladium precatalysts have often been the mainstay for such reactions; however, more investigators are increasingly turning to Earth‐abundant metals (EAMs), in particular nickel precatalysts. Nickel precatalysts have shown to allow for a broad substrate scope, they provide active species in variable oxidation states and demonstrate reactions that often proceed by unique mechanisms. This review will provide guidance on which nickel precatalysts to choose for a given application or which properties to prioritize in reaction development. Discussion points will cover the ease of synthesis, stability, diversity, accessibility, modularity, and general applicability.
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BibTeX
@article{john2026welldefined,
title = {{Well‐Defined Nickel Precatalysts: Form, Function, and Application}},
author = {Morgan E. John and George A. Koutsantonis and Reto Dorta and Scott G. Stewart},
journal = {Chemistry (Weinheim an Der Bergstrasse, Germany)},
year = {2026},
month = aug,
doi = {10.1002/chem.71481},
url = {https://doi.org/10.1002/chem.71481},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Well‐Defined Nickel Precatalysts: Form, Function, and Application
AU - Morgan E. John
AU - George A. Koutsantonis
AU - Reto Dorta
AU - Scott G. Stewart
PY - 2026
DA - 2026/08/07
JO - Chemistry (Weinheim an Der Bergstrasse, Germany)
DO - 10.1002/chem.71481
UR - https://doi.org/10.1002/chem.71481
AB - Modern synthetic methods for the synthesis of pharmaceuticals, fine chemicals, and agrochemicals have been revolutionized by the advent of cross‐coupling chemistry. Well‐defined palladium precatalysts have often been the mainstay for such reactions; however, more investigators are increasingly turning to Earth‐abundant metals (EAMs), in particular nickel precatalysts. Nickel precatalysts have shown to allow for a broad substrate scope, they provide active species in variable oxidation states and demonstrate reactions that often proceed by unique mechanisms. This review will provide guidance on which nickel precatalysts to choose for a given application or which properties to prioritize in reaction development. Discussion points will cover the ease of synthesis, stability, diversity, accessibility, modularity, and general applicability.
SN - 0947-6539
SN - 1521-3765
ER -