Rosa rugosa Root Extract as a Functional Food Ingredient, Mitigating UVB‐Induced Skin Aging Through MAPK/AP‐1 and AGE‐RAGE Pathway Modulation
- 1Food Functionality Research Division Korea Food Research Institute Wanju-gun Jeonbuk-do Republic of Korea.
- 2Division of Food Biotechnology University of Science and Technology Daejeon Republic of Korea.
Abstract
Rosa rugosa root extract (RR-r) has been used in East Asian medicine to treat metabolic disorders, including diabetes and alcohol-induced liver toxicity. Although RR-r has been demonstrated to exhibit anti-inflammatory and antioxidant properties, further research is required to elucidate its protective effects against ultraviolet B (UVB)-induced skin photoaging. In this study, high-performance liquid chromatography was used to identify rutin as the major indicator compound of RR-r. The photoprotective activity of RR-r was evaluated using a mouse model of UVB-induced skin damage. Mice were orally administered RR-r (100 or 200 mg/kg) for 8 weeks during UVB irradiation. RR-r significantly alleviated UVB-induced wrinkle formation, epidermal thickening, and collagen fiber degradation. The assessment of skin morphology and hydration was conducted through the use of histological staining (H&E and Masson's trichrome), wrinkle and moisture analysis, and enzyme-linked immunosorbent assay quantification of hyaluronic acid. Western blotting revealed that RR-r increased pro-collagen type I, tissue inhibitor of metalloproteinases 1, hyaluronan, collagen-1 while reducing the matrix metalloproteinase family, hyaluronidase 1 and hyaluronidase 2. A further mechanistic analysis revealed that RR-r inhibited UVB-induced phosphorylation of mitogen-activated protein kinase pathway components and downstream activator protein-1 factors. Furthermore, RR-r significantly suppressed UVB-induced accumulation of advanced glycation end products (AGEs) and expression of their receptor, RAGE. Collectively, these findings demonstrate that oral RR-r effectively protects against UVB-induced photoaging by regulating wrinkle-related proteins, enhancing skin hydration, and modulating MAPK/AP-1 and AGE-RAGE signaling. Thus, RR-r may represent a promising natural candidate for skin anti-aging interventions.
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BibTeX
@article{gu2026rosa,
title = {{Rosa rugosa Root Extract as a Functional Food Ingredient, Mitigating UVB‐Induced Skin Aging Through MAPK/AP‐1 and AGE‐RAGE Pathway Modulation}},
author = {Min Ji Gu and Guijae Yoo and Sang-Hoon Lee and Ho-Young Park and Yoonsook Kim and Donghwan Kim and Sang Keun Ha},
journal = {Food science \& nutrition},
year = {2026},
month = oct,
doi = {10.1002/fsn3.72462},
url = {https://europepmc.org/article/PMC/PMC13717222},
note = {CC BY},
}
RIS
TY - JOUR
TI - Rosa rugosa Root Extract as a Functional Food Ingredient, Mitigating UVB‐Induced Skin Aging Through MAPK/AP‐1 and AGE‐RAGE Pathway Modulation
AU - Min Ji Gu
AU - Guijae Yoo
AU - Sang-Hoon Lee
AU - Ho-Young Park
AU - Yoonsook Kim
AU - Donghwan Kim
AU - Sang Keun Ha
PY - 2026
DA - 2026/10/28
JO - Food science & nutrition
DO - 10.1002/fsn3.72462
UR - https://europepmc.org/article/PMC/PMC13717222
AB - Rosa rugosa root extract (RR-r) has been used in East Asian medicine to treat metabolic disorders, including diabetes and alcohol-induced liver toxicity. Although RR-r has been demonstrated to exhibit anti-inflammatory and antioxidant properties, further research is required to elucidate its protective effects against ultraviolet B (UVB)-induced skin photoaging. In this study, high-performance liquid chromatography was used to identify rutin as the major indicator compound of RR-r. The photoprotective activity of RR-r was evaluated using a mouse model of UVB-induced skin damage. Mice were orally administered RR-r (100 or 200 mg/kg) for 8 weeks during UVB irradiation. RR-r significantly alleviated UVB-induced wrinkle formation, epidermal thickening, and collagen fiber degradation. The assessment of skin morphology and hydration was conducted through the use of histological staining (H&E and Masson's trichrome), wrinkle and moisture analysis, and enzyme-linked immunosorbent assay quantification of hyaluronic acid. Western blotting revealed that RR-r increased pro-collagen type I, tissue inhibitor of metalloproteinases 1, hyaluronan, collagen-1 while reducing the matrix metalloproteinase family, hyaluronidase 1 and hyaluronidase 2. A further mechanistic analysis revealed that RR-r inhibited UVB-induced phosphorylation of mitogen-activated protein kinase pathway components and downstream activator protein-1 factors. Furthermore, RR-r significantly suppressed UVB-induced accumulation of advanced glycation end products (AGEs) and expression of their receptor, RAGE. Collectively, these findings demonstrate that oral RR-r effectively protects against UVB-induced photoaging by regulating wrinkle-related proteins, enhancing skin hydration, and modulating MAPK/AP-1 and AGE-RAGE signaling. Thus, RR-r may represent a promising natural candidate for skin anti-aging interventions.
SN - 2048-7177
ER -