Skip to content
DraconiticResearch
Search Sources API
203,948 studies31 sourcesUpdated 9 min ago
Peer-reviewedCC BY-NC 4.0Acta Dermato-Venereologica

Prevalence of Contact Sensitization in Patients with Atopic Dermatitis: A Retrospective Study from China

  • Ao Wang1
  • Chengbin Ye1
  • Chengwen Fei1
  • Yingfang Li1
  • Yuelong Ma1
  • Ting Cao1
  • Yue Wu1
  • Yanchun Cheng1
  • Fei Hao1,2
  • Ying Zou1
  1. 1Department of Allergy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
  2. 2Dermatology and Plastic Surgery Center, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China
Read full textPDFDOICite

Abstract

The prevalence of contact sensitization in atopic dermatitis (AD) has been controversial and remains poorly studied in the Chinese population. This retrospective study aimed to assess the prevalence and differences in contact sensitization between AD and non-AD patients undergoing patch testing in China. We analysed clinical records of 3,487 patients who underwent patch testing from 2018 to 2023, including 146 AD patients and 3,341 non-AD patients. Results demonstrated that contact sensitization prevalence was similar in AD and non-AD groups (82.88% vs 84.71%, p=0.55). Common allergens included nickel, methylisothiazolinone, dodecyl gallate and cobalt chloride hexahydrate in both groups. AD patients showed higher positive reactions to hexahydro-1,3,5-tris-(2-hydroxyethyl) triazine (11.11% vs 5.85%, p<0.01), methyldibromo glutaronitrile (10.27% vs 4.97%, p<0.01), quaternium-15 (7.53% vs 3.68%, p=0.02), ethylenediamine dihydrochloride (3.42% vs 0.72%, p<0.01), propylene glycol (2.86% vs 0.60%, p=0.01) and 2-bromo-2-nitropropane-1,3-diol (2.74% vs 0.78%, p=0.03), compared to non-AD, particularly females. Contact sensitization prevalence increased with age in both groups. This study showed that the prevalence of contact sensitization was comparable between the AD and non-AD groups in China. However, AD patients exhibited heightened sensitivity to formaldehyde releasers and propylene glycol, commonly found in moisturizers.

Related

  1. Occupational Allergic Contact Dermatitis due to Rubber Additives in Tunisia: A 27‐Year Retrospective Study of Clinical and Occupational Characteristics
    Emna Baraketi, Jihen Hsinet, Nihel Khouja +1
    Contact DermatitisPeer-reviewedCC BY-NC-ND 4.0Full textGeneral medicinePMC
  2. Associations between use of targeted therapies, hospitalizations, and emergency department visits among patients with atopic dermatitis: A retrospective cohort study
    Richard Ta, Jong Min Jung, Kyu Eun Lee +1
    Journal of Managed Care & Specialty PharmacyPeer-reviewedLicence not statedFull textGeneral medicinePMC
  3. Roflumilast Cream for Residual Disease in Patients With Atopic Dermatitis on Dupilumab: A Retrospective Chart Review Study
    Marley Cutrona, Alexandra K. Golant
    Dermatology and TherapyPeer-reviewedCC BY-NC 4.0Full textGeneral medicinePMCDOAJ
  4. Explorative Correlation of Atopic Dermatitis Control Tool with Minimal Disease Activity Patient-reported Outcomes in Patients Treated with Upadacitinib: A Retrospective Real-world Study
    Filomena Russo, Natale Schettini, Giovanni Scaglione +20
    Acta Dermato-VenereologicaPeer-reviewedCC BY-NCFull textGeneral medicineDOAJEurope PMCPMC
  5. Clinical Characteristics of Patients Presenting with Moderate-to-Severe Atopic Dermatitis and Concomitant Inflammatory Bowel Diseases: a Multicenter Retrospective Study.
    Elena Pezzolo, Maddalena Napolitano, Martina Maurelli +12
    Dermatology practical & conceptualPeer-reviewedCC BY-NCFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{wang2026prevalence,
  title = {{Prevalence of Contact Sensitization in Patients with Atopic Dermatitis: A Retrospective Study from China}},
  author = {Ao Wang and Chengbin Ye and Chengwen Fei and Yingfang Li and Yuelong Ma and Ting Cao and Yue Wu and Yanchun Cheng and Fei Hao and Ying Zou},
  journal = {Acta Dermato-Venereologica},
  year = {2026},
  month = nov,
  doi = {10.2340/actadv.v106.adv-2026-0617},
  url = {https://doi.org/10.2340/actadv.v106.adv-2026-0617},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Prevalence of Contact Sensitization in Patients with Atopic Dermatitis: A Retrospective Study from China
AU  - Ao Wang
AU  - Chengbin Ye
AU  - Chengwen Fei
AU  - Yingfang Li
AU  - Yuelong Ma
AU  - Ting Cao
AU  - Yue Wu
AU  - Yanchun Cheng
AU  - Fei Hao
AU  - Ying Zou
PY  - 2026
DA  - 2026/11/04
JO  - Acta Dermato-Venereologica
DO  - 10.2340/actadv.v106.adv-2026-0617
UR  - https://doi.org/10.2340/actadv.v106.adv-2026-0617
AB  - The prevalence of contact sensitization in atopic dermatitis (AD) has been controversial and remains poorly studied in the Chinese population. This retrospective study aimed to assess the prevalence and differences in contact sensitization between AD and non-AD patients undergoing patch testing in China. We analysed clinical records of 3,487 patients who underwent patch testing from 2018 to 2023, including 146 AD patients and 3,341 non-AD patients. Results demonstrated that contact sensitization prevalence was similar in AD and non-AD groups (82.88% vs 84.71%, p=0.55). Common allergens included nickel, methylisothiazolinone, dodecyl gallate and cobalt chloride hexahydrate in both groups. AD patients showed higher positive reactions to hexahydro-1,3,5-tris-(2-hydroxyethyl) triazine (11.11% vs 5.85%, p<0.01), methyldibromo glutaronitrile (10.27% vs 4.97%, p<0.01), quaternium-15 (7.53% vs 3.68%, p=0.02), ethylenediamine dihydrochloride (3.42% vs 0.72%, p<0.01), propylene glycol (2.86% vs 0.60%, p=0.01) and 2-bromo-2-nitropropane-1,3-diol (2.74% vs 0.78%, p=0.03), compared to non-AD, particularly females. Contact sensitization prevalence increased with age in both groups. This study showed that the prevalence of contact sensitization was comparable between the AD and non-AD groups in China. However, AD patients exhibited heightened sensitivity to formaldehyde releasers and propylene glycol, commonly found in moisturizers.
SN  - 0001-5555
SN  - 1651-2057
ER  -