Clinical Characteristics of Patients Presenting with Moderate-to-Severe Atopic Dermatitis and Concomitant Inflammatory Bowel Diseases: a Multicenter Retrospective Study.
15 affiliations
- 1Department of Dermatology, San Bortolo Hospital, Vicenza, Italy.
- 2Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
- 3Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.
- 4Department of Precision and Regenerative Medicine and Jonian Area, Unit of Dermatology, University of Bari Aldo Moro, Bari, Italy.
- 5Dermatology Unit, Arcispedale S. Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
- 6Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy.
- 7Department of Clinical and Experimental Sciences, Dermatology Unit, University of Brescia, Brescia, Italy.
- 8Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
- 9UOSD General and Oncologic Dermatology, San Salvatore Hospital, L'Aquila, Italy.
- 10Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
- 11Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
- 12Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
- 13Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola Malpighi, Bologna, Italy.
- 14IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
- 15Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Abstract
Introduction
Atopic dermatitis (AD) and inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated disorders with overlapping immunopathogenic mechanisms. Limited research has investigated clinical features of AD and concomitant IBD.Objectives
This study aimed to evaluate the clinical presentation of adult patients with concomitant moderate-to-severe AD and IBD.Methods
Adult patients with moderate-to-severe AD and confirmed IBD were identified across 12 hospital-based dermatology centers between 2022 and 2024 by using electronic records.Results
Thirty-eight out of 4,236 (0.9%) patients with moderate-to-severe AD had verified IBD (19 CD and 19 UC), with a prevalence higher than that expected in the general Italian population (0.9% vs 0.41%). The mean age at AD diagnosis was 25 years, with AD preceding IBD diagnosis with a median interval of 10 years in 71% of cases. At the time of the study, 40% of CD patients and 63% of UC patients were in clinical remission. AD clinical presentation in patients with IBD was typical, with 68% of patients presenting with flexural phenotype, and associated with personal (34%) or family (40%) history of atopy.Conclusions
IBD is not frequent in AD patients, but the prevalence seems to be higher compared to the general population. AD occurring with IBD had a typical clinical presentation. Interestingly, occurrence of AD preceded IBD onset in most patients, putting dermatologists in the position to make early IBD diagnosis. However, no direct causal relationship can be drawn from these findings. Larger, controlled prospective studies are needed to clarify the relationship between AD and IBD.
Related
- Brolucizumab-Associated Ocular Complications with Concomitant Sub-Tenon Triamcinolone Acetonide: A Multicenter Retrospective Study
- Clinical Characteristics, Etiologies, and Outcomes of Adults Presenting With Altered Mental Status to the Emergency Department: A Retrospective Cohort Study.
- Clinical Characteristics and Mortality Predictors of Group B Streptococcus Bacteremia in Adults: A Multicenter Retrospective Cohort Study in Japan, 2015-2024.
- Clinical Characteristics of Respiratory Syncytial Virus Infection in Korean Children: An 11-Year Multicenter Retrospective Study.
- Patient characteristics, fracture distribution and management patterns of incomplete thoracolumbar burst fractures: Results from a retrospective multicenter cohort of 982 patients.
BibTeX
@article{pezzolo2026clinical,
title = {{Clinical Characteristics of Patients Presenting with Moderate-to-Severe Atopic Dermatitis and Concomitant Inflammatory Bowel Diseases: a Multicenter Retrospective Study.}},
author = {Elena Pezzolo and Maddalena Napolitano and Martina Maurelli and Caterina Foti and Vito Di Lernia and Michela Ortoncelli and Mariateresa Rossi and Cataldo Patruno and Maria Esposito and Niccolò Gori and Carlotta Gurioli and Ylenia Vallone and Francesca Peccerillo and Alessandro Armuzzi and Giampiero Girolomoni},
journal = {Dermatology practical \& conceptual},
year = {2026},
month = jul,
doi = {10.5826/dpc.1603a6643},
url = {https://europepmc.org/article/MED/42858396},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Clinical Characteristics of Patients Presenting with Moderate-to-Severe Atopic Dermatitis and Concomitant Inflammatory Bowel Diseases: a Multicenter Retrospective Study.
AU - Elena Pezzolo
AU - Maddalena Napolitano
AU - Martina Maurelli
AU - Caterina Foti
AU - Vito Di Lernia
AU - Michela Ortoncelli
AU - Mariateresa Rossi
AU - Cataldo Patruno
AU - Maria Esposito
AU - Niccolò Gori
AU - Carlotta Gurioli
AU - Ylenia Vallone
AU - Francesca Peccerillo
AU - Alessandro Armuzzi
AU - Giampiero Girolomoni
PY - 2026
DA - 2026/07/31
JO - Dermatology practical & conceptual
DO - 10.5826/dpc.1603a6643
UR - https://europepmc.org/article/MED/42858396
AB - Introduction Atopic dermatitis (AD) and inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated disorders with overlapping immunopathogenic mechanisms. Limited research has investigated clinical features of AD and concomitant IBD.Objectives This study aimed to evaluate the clinical presentation of adult patients with concomitant moderate-to-severe AD and IBD.Methods Adult patients with moderate-to-severe AD and confirmed IBD were identified across 12 hospital-based dermatology centers between 2022 and 2024 by using electronic records.Results Thirty-eight out of 4,236 (0.9%) patients with moderate-to-severe AD had verified IBD (19 CD and 19 UC), with a prevalence higher than that expected in the general Italian population (0.9% vs 0.41%). The mean age at AD diagnosis was 25 years, with AD preceding IBD diagnosis with a median interval of 10 years in 71% of cases. At the time of the study, 40% of CD patients and 63% of UC patients were in clinical remission. AD clinical presentation in patients with IBD was typical, with 68% of patients presenting with flexural phenotype, and associated with personal (34%) or family (40%) history of atopy.Conclusions IBD is not frequent in AD patients, but the prevalence seems to be higher compared to the general population. AD occurring with IBD had a typical clinical presentation. Interestingly, occurrence of AD preceded IBD onset in most patients, putting dermatologists in the position to make early IBD diagnosis. However, no direct causal relationship can be drawn from these findings. Larger, controlled prospective studies are needed to clarify the relationship between AD and IBD.
SN - 2160-9381
ER -