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Peer-reviewedCC BY-NC-ND 4.0Communications Biology

Resorantel: a dual-targeting therapeutic with potent efficacy against Staphylococcus aureus with low potential for drug resistance

  • Pengfei She1
  • Shaowei Guo2,3
  • Dan Xiao2,3
  • Guanqing Huang2,4
  • Yiqing Liu2,4
  • Mengna Li2,4
  • Lihua Lu2,3
  • Yelan Hong2,3
  • Yong Wu2,3
4 affiliations
  1. 1Department of Laboratory Medicine, The Third Xiangya Hospital of Central South University, Changsha, China
  2. 2The First Hospital of Changsha (The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University), Changsha, China
  3. 3Graduate Collaborative Training Base of The First Hospital of Changsha, Hengyang Medical College, University of South China, Hengyang, China
  4. 4Department of Laboratory Medicine, Xiangya Hospital of Central South University, Changsha, China
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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a significant public health concern. The biofilm formation capability of MRSA is often associated with high levels of antimicrobial resistance. Therefore, the development of novel therapeutic strategies to combat MRSA is urgently warranted. By drug repurposing, resorantel, originally developed as an antiparasitic agent, has demonstrated significantly bactericidal activity against MRSA and its biofilms with effectively inhibitory activity against the emergence of drug resistance. Furthermore, resorantel displayed significant in vivo antibacterial efficacy in both topic and systemic infection models. Mechanistic investigations employing transcriptomics, fluorescent probes, molecular dynamics simulations, and surface plasmon resonance analysis revealed that proton motive force and MurB are likely the potential targets of resorantel. Collectively, this study identifies resorantel as a promising novel antimicrobial agent with potential for use in the treatment of MRSA and its biofilm-related infections.

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Cite

BibTeXRIS
BibTeX
@article{she2026resorantel,
  title = {{Resorantel: a dual-targeting therapeutic with potent efficacy against Staphylococcus aureus with low potential for drug resistance}},
  author = {Pengfei She and Shaowei Guo and Dan Xiao and Guanqing Huang and Yiqing Liu and Mengna Li and Lihua Lu and Yelan Hong and Yong Wu},
  journal = {Communications Biology},
  year = {2026},
  month = jul,
  doi = {10.1038/s42003-026-10591-4},
  url = {https://doi.org/10.1038/s42003-026-10591-4},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Resorantel: a dual-targeting therapeutic with potent efficacy against Staphylococcus aureus with low potential for drug resistance
AU  - Pengfei She
AU  - Shaowei Guo
AU  - Dan Xiao
AU  - Guanqing Huang
AU  - Yiqing Liu
AU  - Mengna Li
AU  - Lihua Lu
AU  - Yelan Hong
AU  - Yong Wu
PY  - 2026
DA  - 2026/07/02
JO  - Communications Biology
DO  - 10.1038/s42003-026-10591-4
UR  - https://doi.org/10.1038/s42003-026-10591-4
AB  - Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a significant public health concern. The biofilm formation capability of MRSA is often associated with high levels of antimicrobial resistance. Therefore, the development of novel therapeutic strategies to combat MRSA is urgently warranted. By drug repurposing, resorantel, originally developed as an antiparasitic agent, has demonstrated significantly bactericidal activity against MRSA and its biofilms with effectively inhibitory activity against the emergence of drug resistance. Furthermore, resorantel displayed significant in vivo antibacterial efficacy in both topic and systemic infection models. Mechanistic investigations employing transcriptomics, fluorescent probes, molecular dynamics simulations, and surface plasmon resonance analysis revealed that proton motive force and MurB are likely the potential targets of resorantel. Collectively, this study identifies resorantel as a promising novel antimicrobial agent with potential for use in the treatment of MRSA and its biofilm-related infections.
SN  - 2399-3642
ER  -