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Peer-reviewedCC BYFood science & nutrition

Integrated Multi-Omics Analysis of Polygonatum odoratum Polysaccharide in D-Galactose-Treated Mice Reveals Changes in Oxidative Stress Markers and Gut Microbiota.

  • Wenjian Li1,2
  • Yan Huang3
  • Wenfang Zhang1
  • Shunxiang Li1,2,4
  • Lisong Li5
5 affiliations
  1. 1School of Pharmacy Hunan University of Chinese Medicine Changsha China.
  2. 2Hunan Province Engineering Technology Research Center of Bioactive Substance Discovery of Chinese Medicine Changsha China.
  3. 3Hunan Province Hospital of Integrated Traditional Chinese and Western Medicine (Affiliated Hospital of Hunan Academy of Chinese Medicine) Changsha China.
  4. 4Hunan Province Sino-US International Joint Research Center for Therapeutic Drugs of Senile Degenerative Diseases Changsha China.
  5. 5School of Informatics Hunan University of Chinese Medicine Changsha China.
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Abstract

Age-related changes are associated with oxidative stress, metabolic dysregulation, and alterations in the gut microbiota. Although Polygonatum odoratum polysaccharide (POP) has shown antioxidant and neuroprotective effects, its associations with gut bacterial composition, circulating metabolites, and tissue gene expression remain unclear. Using a D-galactose-treated mouse model, we assessed hippocampal histology and oxidative stress markers and performed bacterial 16S rRNA sequencing, untargeted serum metabolomics, and hippocampal and colonic transcriptomic analyses. POP treatment was associated with improved hippocampal histology, reduced malondialdehyde levels, and increased glutathione levels and superoxide dismutase activity. It was also associated with changes in selected gut bacterial taxa and serum lipid metabolites, lower expression of NF-κB-related genes (Btk, Lat, and Tnfrsf13c) in the colon, and lower Ninj2 expression in the hippocampus. Cross-omics analysis identified correlations among these bacterial, metabolite, and gene-expression features. These findings identify candidate gut-serum-tissue associations accompanying the effects of POP in D-galactose-treated mice. Functional studies are needed to determine whether any of these changes mediate its effects.

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Cite

BibTeXRIS
BibTeX
@article{li2026integrated,
  title = {{Integrated Multi-Omics Analysis of Polygonatum odoratum Polysaccharide in D-Galactose-Treated Mice Reveals Changes in Oxidative Stress Markers and Gut Microbiota.}},
  author = {Wenjian Li and Yan Huang and Wenfang Zhang and Shunxiang Li and Lisong Li},
  journal = {Food science \& nutrition},
  year = {2026},
  month = oct,
  doi = {10.1002/fsn3.72500},
  url = {https://europepmc.org/article/MED/42953387},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Integrated Multi-Omics Analysis of Polygonatum odoratum Polysaccharide in D-Galactose-Treated Mice Reveals Changes in Oxidative Stress Markers and Gut Microbiota.
AU  - Wenjian Li
AU  - Yan Huang
AU  - Wenfang Zhang
AU  - Shunxiang Li
AU  - Lisong Li
PY  - 2026
DA  - 2026/10/28
JO  - Food science & nutrition
DO  - 10.1002/fsn3.72500
UR  - https://europepmc.org/article/MED/42953387
AB  - Age-related changes are associated with oxidative stress, metabolic dysregulation, and alterations in the gut microbiota. Although Polygonatum odoratum polysaccharide (POP) has shown antioxidant and neuroprotective effects, its associations with gut bacterial composition, circulating metabolites, and tissue gene expression remain unclear. Using a D-galactose-treated mouse model, we assessed hippocampal histology and oxidative stress markers and performed bacterial 16S rRNA sequencing, untargeted serum metabolomics, and hippocampal and colonic transcriptomic analyses. POP treatment was associated with improved hippocampal histology, reduced malondialdehyde levels, and increased glutathione levels and superoxide dismutase activity. It was also associated with changes in selected gut bacterial taxa and serum lipid metabolites, lower expression of NF-κB-related genes (Btk, Lat, and Tnfrsf13c) in the colon, and lower Ninj2 expression in the hippocampus. Cross-omics analysis identified correlations among these bacterial, metabolite, and gene-expression features. These findings identify candidate gut-serum-tissue associations accompanying the effects of POP in D-galactose-treated mice. Functional studies are needed to determine whether any of these changes mediate its effects.
SN  - 2048-7177
ER  -