Peer-reviewedCC BYArchives of orthopaedic and trauma surgery14 Oct 2026

Epidemiology, determinants, and microbiological profile of implant-associated infections following intramedullary nailing in a tertiary hospital in Ethiopia.

Abebaw Muhabaw Zegeye¹
Suleiman Ayalew Belay²
Ephrem Bekele Kebede¹
Birlew Teshome Alemayehu¹
Sileshi Serebe Zeleke¹
Yohannis Derbew Molla¹

¹University of Gondar, Gonder, Ethiopia.
²University of Gondar, Gonder, Ethiopia. [email protected].

Abstract

Background

Implant-associated infections after intramedullary nailing (IMN) are a major cause of morbidity in patients with long bone fractures. This study aimed to determine the magnitude, determinants, and microbiological profile of such infections in a tertiary hospital in Ethiopia.Methods

A hospital-based cross-sectional study was conducted among 260 patients who underwent IMN for lower extremity long bone fractures between January 2021 and December 2023. Clinical data, operative details, and microbiological results were collected, and logistic regression was applied to identify determinants of infection.Results

The overall infection rate was 8.46% (95% CI: 5.38-12.53; 22/260), comprising 4.62% deep and 3.85% superficial infections. We found that emergency surgery and hospital stay longer than 14 days were independently associated with an increased risk of infection. Among the limited number of culture-positive infections, Gram-negative bacteria predominated, with Escherichia coli as the most frequently identified pathogen.Conclusion

The infection rate was higher than in many other settings, underscoring the need for improved perioperative infection prevention and reduced hospital stays. Findings highlight the importance of perioperative optimization and hospital infection control in LMICs.

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Cite

BibTeX RIS

BibTeX

@article{zegeye2026epidemiology,
  title = {{Epidemiology, determinants, and microbiological profile of implant-associated infections following intramedullary nailing in a tertiary hospital in Ethiopia.}},
  author = {Abebaw Muhabaw Zegeye and Suleiman Ayalew Belay and Ephrem Bekele Kebede and Birlew Teshome Alemayehu and Sileshi Serebe Zeleke and Yohannis Derbew Molla},
  journal = {Archives of orthopaedic and trauma surgery},
  year = {2026},
  month = oct,
  doi = {10.1007/s00402-026-06535-6},
  url = {https://europepmc.org/article/MED/42873356},
  note = {CC BY},
}

RIS

TY  - JOUR
TI  - Epidemiology, determinants, and microbiological profile of implant-associated infections following intramedullary nailing in a tertiary hospital in Ethiopia.
AU  - Abebaw Muhabaw Zegeye
AU  - Suleiman Ayalew Belay
AU  - Ephrem Bekele Kebede
AU  - Birlew Teshome Alemayehu
AU  - Sileshi Serebe Zeleke
AU  - Yohannis Derbew Molla
PY  - 2026
DA  - 2026/10/14
JO  - Archives of orthopaedic and trauma surgery
DO  - 10.1007/s00402-026-06535-6
UR  - https://europepmc.org/article/MED/42873356
AB  - Background  Implant-associated infections after intramedullary nailing (IMN) are a major cause of morbidity in patients with long bone fractures. This study aimed to determine the magnitude, determinants, and microbiological profile of such infections in a tertiary hospital in Ethiopia.Methods  A hospital-based cross-sectional study was conducted among 260 patients who underwent IMN for lower extremity long bone fractures between January 2021 and December 2023. Clinical data, operative details, and microbiological results were collected, and logistic regression was applied to identify determinants of infection.Results  The overall infection rate was 8.46% (95% CI: 5.38-12.53; 22/260), comprising 4.62% deep and 3.85% superficial infections. We found that emergency surgery and hospital stay longer than 14 days were independently associated with an increased risk of infection. Among the limited number of culture-positive infections, Gram-negative bacteria predominated, with Escherichia coli as the most frequently identified pathogen.Conclusion  The infection rate was higher than in many other settings, underscoring the need for improved perioperative infection prevention and reduced hospital stays. Findings highlight the importance of perioperative optimization and hospital infection control in LMICs.
SN  - 0936-8051
SN  - 1434-3916
ER  -

Abstract

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