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Peer-reviewedCC BY-NC-NDAmerican journal of physiology. Lung cellular and molecular physiology

Dynamics of Airway Macrophage Responses and Lung Function Changes after Ozone Exposure in Humans

  • Jared Radbel1,2
  • Emily R. Stevenson3
  • Raymond C. Rancourt3
  • Kathleen G. Black2
  • Adriana De Resende2
  • Derek Ge1
  • Aesha Jobanputra1
  • Jessica Cervelli3
  • Jeffrey D. Laskin4,2
  • Howard M. Kipen4,2
  • Andrew J. Gow3,2
  • Debra L. Laskin3,2
4 affiliations
  1. 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA
  2. 2Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey, USA
  3. 3Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey, USA
  4. 4Department of Environmental and Occupational Health and Justice, Rutgers School of Public Health, Piscataway, New Jersey, USA
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Abstract

Macrophage involvement in the human response to ozone remains poorly defined. In this human crossover exposure study, we characterized ozone-induced changes in airway macrophage populations at 24, 48, and 72 h post-exposure. Ozone exposure caused immediate declines in pulmonary function, which improved 24-72 h later; recovery was associated with increases in airway monocyte-derived macrophage-to-neutrophil and monocyte-derived macrophage-to-monocyte ratios. These findings highlight coordinated, time-related macrophage dynamics that may contribute to recovery from ozone-induced lung injury.

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Cite

BibTeXRIS
BibTeX
@article{radbel2026dynamics,
  title = {{Dynamics of Airway Macrophage Responses and Lung Function Changes after Ozone Exposure in Humans}},
  author = {Jared Radbel and Emily R. Stevenson and Raymond C. Rancourt and Kathleen G. Black and Adriana De Resende and Derek Ge and Aesha Jobanputra and Jessica Cervelli and Jeffrey D. Laskin and Howard M. Kipen and Andrew J. Gow and Debra L. Laskin},
  journal = {American journal of physiology. Lung cellular and molecular physiology},
  year = {2026},
  month = sep,
  doi = {10.1152/ajplung.00120.2026},
  url = {https://doi.org/10.1152/ajplung.00120.2026},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Dynamics of Airway Macrophage Responses and Lung Function Changes after Ozone Exposure in Humans
AU  - Jared Radbel
AU  - Emily R. Stevenson
AU  - Raymond C. Rancourt
AU  - Kathleen G. Black
AU  - Adriana De Resende
AU  - Derek Ge
AU  - Aesha Jobanputra
AU  - Jessica Cervelli
AU  - Jeffrey D. Laskin
AU  - Howard M. Kipen
AU  - Andrew J. Gow
AU  - Debra L. Laskin
PY  - 2026
DA  - 2026/09/21
JO  - American journal of physiology. Lung cellular and molecular physiology
DO  - 10.1152/ajplung.00120.2026
UR  - https://doi.org/10.1152/ajplung.00120.2026
AB  - Macrophage involvement in the human response to ozone remains poorly defined. In this human crossover exposure study, we characterized ozone-induced changes in airway macrophage populations at 24, 48, and 72 h post-exposure. Ozone exposure caused immediate declines in pulmonary function, which improved 24-72 h later; recovery was associated with increases in airway monocyte-derived macrophage-to-neutrophil and monocyte-derived macrophage-to-monocyte ratios. These findings highlight coordinated, time-related macrophage dynamics that may contribute to recovery from ozone-induced lung injury.
SN  - 1040-0605
SN  - 1522-1504
ER  -