Biochemistry & molecular biology
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- Mechanisms of fork stalling and reversal at pathogenic CANVAS (AAGGG)n repeats
- Selective tRNA charging defects reshape ribosomal pausing and stress adaptation
- Efficient translation of chaperones by eIF5A safeguards proteostasis under heat stress
- Pho92 direct interaction with Not1 recruits the CCR4-NOT complex to m6A containing mRNAs to modulate meiosis in S. cerevisiae
- Two closely related RNA helicases, UAP56 and URH49, couple mRNA splicing and export pathways with their distinct complexes
- Proteomic clocks reveal organ-specific signatures of aging in mice
- Disrupted RGS coupling underlies a clinically distinct subset of GNAO1-related disorder
- Thylakoid plasticity primes photoprotection in diatoms
- Acetylation facilitates NPM1 anchoring in the nucleolus by boosting liquid-liquid phase separation
- A novel metalloprotease family discovered through a tardigrade
- Optimisation and Validation of a UHPLC-MS/MS Assay Using Timed Post-Column Ammonium Fluoride Infusion for Sensitive Serum Steroids Quantitation
- Viscoelastic liquid lassos extend the defensive reach of termite soldiers
- Who contributes to whom: following the evidence behind protein language-model predictions of backbone variability
- Photoactivatable Rac1: a photosensor tilt by time-resolved crystallography and a partially open switch I when GDP-bound
- CODMA-A3: A Competitive Oligo-based DNA Modification Assay Applied to APOBEC Enzymes
- Gastric resection and restriction yield distinct neuroendocrine and metabolic outcomes in obese mice
- A Binding Site for CVN293 Reveals a Mechanism for Allosteric Control of THIK-1 K2P Channel Gating
- Bayesian in situ point spread function modeling enables high-fidelity three-dimensional nanoscopy in deep tissue
- The COL4A3 c.3418+1G>T variant causes exon 39 skipping in minigene assays: functional and exploratory structural analyses
- Linking systemic inflammation nutrition status to the tumor immune microenvironment: integrated biomarkers of neoadjuvant response in locally advanced rectal cancer
- Paired metabolomics identify associations between fecal and serum metabolites in cardiovascular-kidney-metabolic syndrome
- Identification of metabolic vulnerabilities and synthetic lethal targets utilizing artificial intelligence-driven precision medicine
- Deciphering the gut-lung axis in non-small cell lung cancer: from immune microenvironment crosstalk to clinical translation
- Xiaoai Jiedu recipe promotes NLRP3 inflammasome activation by alleviating PINK1-mediated mitophagy in hepatocellular carcinoma
- Editorial: Unlocking the potential of extracellular vesicles in tumor immunity and drug resistance