Medicinal chemistry & drug discovery
161 studies18 in 7 days47 in 30 days
Filters
Latest
161 studies
- Chimpanzee-Guided Discovery of a Non-Native Bioactive Plant
- Antiviral amide derivatives from Uvaria siamensis
- Utilizing Light to Control Glycopolymer–DC-SIGN Interactions via Molecular Motors
- Exposure to Short Dry Phases Prevents Hatching of Mayfly Egg Masses
- Colorectal Cancer at the Crossroads: The Good, the Bad, and the Future of Platinum-Based Drugs
- Granulated Ammonium Alginate as a Functional Sodium-Sequestration Agent: Formulation Optimization Using Box–Behnken Design
- Efficient visualization of chemical space
- Ni(II) Complexes of 2-Imine-8-Hydroxyquinolines: Characterization, Albumin Binding and Cytotoxicity
- Novel Triazole-Adenosine Conjugates as Mammalian Seryl-tRNA Synthetase Inhibitors to protect cells from Ischemia-Reperfusion Injury
- N8‐Modified Quino[4,3,2‐Kl]acridines as Promising Antimalarial G‐Quadruplex Ligands
- Essential Oils of Ocimum basilicum L. and Ocimum americanum L. from Djibouti: Chemical Composition, Antimicrobial and Cytotoxicity Evaluations
- Unprecedented Synthesis of a Terminal Dialkynyl Primary Carbinamine: A Bioinspired Lipid With Cytotoxic Activities
- UniCure: A multi-modal model for predicting personalized cancer therapy response
- Homolysis of Alkoxyamines Triggered by Carbohydrate-Active Enzyme: A Step toward a General Platform to Generate Toxic Alkyl Radicals
- An interpretable framework applying protein words to predict protein–small molecule complementary pairing rules
- The Molecular Bases of the Interaction between a Saponin from the Roots of Gypsophila paniculata L. and Model Lipid Membranes
- Ru‐Catalyzed Asymmetric Transfer Hydrogenation of α‐iminophosphonates: A Novel Synthetic Approach for Valuable Chiral α‐Aminophosphonates
- AI-enhanced adaptive virtual screening of large libraries for ligand discovery
- PCIM-DTA: pairwise conditional interaction modeling for drug–target affinity prediction under cold-start scenarios
- Optimized alkyne-modified pyridylpiperazine efflux pump inhibitors overcome intrinsic macrolide resistance in multidrug-resistant Klebsiella pneumoniae isolates
- Influence of Lipid Thioether Modification and Formulation Method on Lipoplex Structure, Stability and Transfection Efficiency in HEK293T Cells
- Integrated Approach for the Discovery of Antifungal and Antibiofilm Agents From Cerrado Plants
- Mesoporous silica–coated gold nanorods functionalized with the D3 peptide and loaded with epigallocatechin-3-gallate reduce β-amyloid toxicity in the presence of Zn(II) ions
- Identification of novel serotonin transporter (SERT) inhibitors via large-scale machine learning-based virtual screening and molecular dynamics simulations
- Automated transition state generation for mechanistic exploration in organic synthesis