Pharmacology & toxicology
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- DNA-Encoded Library-Guided Discovery of a First-in-Class Molecular Glue of the NOS1AP-SCRIB Complex in Alzheimer's Disease Patient-Derived Neurons
- AT1R-Selective Negative Allosteric Modulator Targeting the Epitope for Pathogenic Autoantibody Activation
- Part 1 of a 2-part, open-label clinical trial evaluating repeated nicotinamide riboside parenteral administration: 3 consecutive days of intramuscular and subcutaneous injections
- Whole-exome sequencing reveals cumulative rare variant burden associated with susceptibility to anti-tuberculosis drug-induced liver injury in a Han Chinese cohort
- Mortality associations with overlapping PM2.5 pollution waves and cold events in Hebei Province, China: a county-level two-stage time-series study
- Associations of short-term exposure to multiple air pollutants with hospital admissions for ischemic stroke in Lanzhou, China
- Individual-level health effects of living near a gas-fired "Peaker" power plant.
- Guidelines for the management of adult penicillin allergy in community and specialist settings in Australia and New Zealand: An AGREE II and Delphi-based approach.
- 12-month weight-loss trajectories and predictors of response to tirzepatide under individualized dosing: A multicenter real-world study.
- Weight loss and blood pressure lowering with GLP-1 receptor agonists and multi-hormone receptor modulators in overweight and obesity: a systematic review and meta-regression of phase 3 clinical trials
- PAH-associated health risk from ultrafine particles: an urban field study.
- C-Reactive Protein and Risk of Low Back Pain: A Univariable and Multivariable Mendelian Randomization Study.
- The challenges of direct Claisen–Schmidt condensation in the synthesis of polyhydroxylated bischalcones: experimental results supported by DFT calculations
- Toward Chemoselective Modification of Selenocysteine-Containing Biomolecules Via Doubly Activated Cyclopropanes
- Isolation, Characterization, and Phytotoxic Activity of Streptomyces spp. from Diseased Potato Scab Tubers
- From environmental occurrence to human exposure: multisystem toxicity, immune-relevant mechanisms, and gaps in health-risk assessment of liquid crystal monomers
- WRN helicase addiction in MSI-H colorectal cancer: biomarker-guided pharmacology, resistance evolution, and implications for other gastrointestinal cancers
- Flavonoids in cancer pharmacology: molecular mechanisms, tumor microenvironment regulation, and drug resistance
- Berberine ameliorates thioacetamide-induced liver injury in zebrafish through PPARγ signaling and restores bile acid homeostasis
- Thermal Stability of Aliphatic and Semiaromatic Polyamides: Tailoring the Choice of Isothermal Aging Temperature by Using Kinetic Models of Degradation
- Ecological and pathological factors related to trace metal concentrations in harbour porpoises Phocoena phocoena from the North Sea and adjacent areas
- The SChISM study: Circulating cell-free DNA size profiles as predictors of progression in advanced carcinoma treated with immune-checkpoint inhibitors
- Hydrodynamically decoupled nanoprecipitation (HDNP): A multi-stage strategy for supersaturation, controlled delayed nucleation, and stabilization of low LogP poorly-water soluble drugs
- Exercise oncology and tumor sterol metabolism: An emerging mechanistic frontier
- Lead-containing radiation-attenuating sterile gloves in simulated use: Lead transfer to sweat as an unknown risk to users