Dietary glucoraphenin ameliorates obesity and steatotic liver disease associated with gut dysbiosis induced by a Western diet in mice
- 1Food Functionality Research Division, Korea Food Research Institute, Wanju-gun, Republic of Korea
- 2Department of Food Biotechnology, University of Science and Technology, Daejeon, Republic of Korea
- 3Hamsoa Pharmaceutics, Iksan, Republic of Korea
Abstract
Western-style diets promote obesity, gut dysbiosis, and metabolic dysfunction-associated steatotic liver disease (MASLD). In this study, glucoraphenin (GRE), the major glucosinolate in radish (Raphanus sativus L.) greens and sprouts, was evaluated for its effects on Western diet (WD)-induced metabolic derangements and gut dysfunction in mice. Intaking of 1 mg/kg body weight of GRE with WD for 8 weeks caused significant reductions in adipogenesis indicators such as body weight gains, adipocyte hypertrophy, and serum leptin level. This result was further proved by significant changes in lipogenesis and lipolysis-related protein expressions in adipocyte. Administration of GRE also suppressed development of MASLD, which was observed through reductions in serum ALT and AST and suppressions the expression of FAS, SREBP1, mTOR, SCD1, ACC, and ChREBP in liver tissues. GRE administration effectively prevented the decrease in the gut microbial richness and diversity caused by WD and recovered serum branched-chain amino acids and microbiota-derived purine metabolites (inosine and hypoxanthine). These findings indicate that GRE mitigates WD-induced obesity and MASLD via coordinated regulation of lipid metabolism and the gut–liver axis.
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BibTeX
@article{lee2026dietary,
title = {{Dietary glucoraphenin ameliorates obesity and steatotic liver disease associated with gut dysbiosis induced by a Western diet in mice}},
author = {Hye-Bin Lee and Yu Ra Lee and Hee-Jin Kim and Inwook Choi and Miri Park and Seong Un Jeong and Jae-Hyun Yoon and Ho-Young Park},
journal = {NPJ Science of Food},
year = {2026},
month = jul,
doi = {10.1038/s41538-026-01000-5},
url = {https://doi.org/10.1038/s41538-026-01000-5},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Dietary glucoraphenin ameliorates obesity and steatotic liver disease associated with gut dysbiosis induced by a Western diet in mice
AU - Hye-Bin Lee
AU - Yu Ra Lee
AU - Hee-Jin Kim
AU - Inwook Choi
AU - Miri Park
AU - Seong Un Jeong
AU - Jae-Hyun Yoon
AU - Ho-Young Park
PY - 2026
DA - 2026/07/11
JO - NPJ Science of Food
DO - 10.1038/s41538-026-01000-5
UR - https://doi.org/10.1038/s41538-026-01000-5
AB - Western-style diets promote obesity, gut dysbiosis, and metabolic dysfunction-associated steatotic liver disease (MASLD). In this study, glucoraphenin (GRE), the major glucosinolate in radish (Raphanus sativus L.) greens and sprouts, was evaluated for its effects on Western diet (WD)-induced metabolic derangements and gut dysfunction in mice. Intaking of 1 mg/kg body weight of GRE with WD for 8 weeks caused significant reductions in adipogenesis indicators such as body weight gains, adipocyte hypertrophy, and serum leptin level. This result was further proved by significant changes in lipogenesis and lipolysis-related protein expressions in adipocyte. Administration of GRE also suppressed development of MASLD, which was observed through reductions in serum ALT and AST and suppressions the expression of FAS, SREBP1, mTOR, SCD1, ACC, and ChREBP in liver tissues. GRE administration effectively prevented the decrease in the gut microbial richness and diversity caused by WD and recovered serum branched-chain amino acids and microbiota-derived purine metabolites (inosine and hypoxanthine). These findings indicate that GRE mitigates WD-induced obesity and MASLD via coordinated regulation of lipid metabolism and the gut–liver axis.
SN - 2396-8370
ER -