Skip to content
DraconiticResearch
Search Sources API
190,335 studies31 sourcesUpdated 48 min ago
Peer-reviewedCC BY-NC-NDAnnals of hematology

Waldenstrom's macroglobulinemia in siblings: a single institutional experience with 10 cases at 25 years and a review of the literature.

  • Lingling Wang1
  • Yongfen Huang1
  • Hui Chen1
  • Jianming Dong1
  • Hao Xu1
  • Yuqing Miao1
  • Yuexin Cheng2
  1. 1Department of Hematology, The First People's Hospital of Yancheng, The Yancheng Clinical College of Xuzhou Medical University, Yancheng, Jiangsu, People's Republic of China.
  2. 2Department of Hematology, The First People's Hospital of Yancheng, The Yancheng Clinical College of Xuzhou Medical University, Yancheng, Jiangsu, People's Republic of China. [email protected].
Read full textPDFDOICite

Abstract

Waldenstrom's macroglobulinemia (WM) is characterized by familial aggregation. The study displayed the characteristics and outcomes of patients with WM in siblings. Ten cases (five pairs) were recognized as WM in siblings. The earliest pair (cases 3 and 4) was identified in 2002 and 2005, respectively, while the recent pair (cases 7 and 8) was confirmed in 2022. Males accounted for 90%. The median age at diagnosis was 65.5 years (range, 51-71 years). Rituximab-based immunochemotherapy was initiated in three patients, whereas regimens based on nucleoside analogs and alkylating drugs were initiated in five patients. As of December 2024, three patients died from severe infection, while one died from traumatic injury. Our investigation discovered no significant difference between WM in siblings and sporadic WM in terms of gender, age, ECOG score, B symptoms, with or without BTKi exposure, IPSS-WM score, Hb, PLT, LDH, β2-MG, IgM, albumin, hepatosplenomegaly, lymphadenopathy, and MYD88L265P. Median overall survival was 230 months for patients with familial WM among siblings and 96 months for those with sporadic WM (p = 0.2, HR: 0.6, 95% CIs: 0.2-1). This study provided an overview of the screening initiatives for WM in siblings in the hospital population and follow-up results for five pairs of WM in siblings. The incidence of WM in siblings in the real world may be underestimated.

Related

  1. Waldenström macroglobulinemia presenting with lumbar vertebral fracture as the initial symptom: a rare case report and literature review
    Li Xu, Chen Shen, Jian Mi +5
    Frontiers in MedicinePeer-reviewedCC BYFull textHuman geneticsDOAJ
  2. Relapsed Waldenström macroglobulinemia presenting as bilateral parotid gland enlargement with multiple cystic lesions : A case report
    Hsin-Yao Hung, Yu-Cheng Chang, Tsung-Yu Yen
    MedicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  3. Severe Aplastic Anemia Concurrent with Lymphoplasmacytic Lymphoma/Waldenström's Macroglobulinemia
    Takehiro Okuda, Yuta Hanyu, Hana Mineshige +12
    Internal MedicinePeer-reviewedCC BY-NC-NDFull textHuman geneticsJ-STAGE
  4. UMA RARA ASSOCIAÇÃO ENTRE MACROGLOBULINEMIA DE WALDENSTRÖM E LINFOMA DE HODGKIN CLÁSSICO: RELATO DE CASO
    Amanda Carvalho HIPOLITO VIZZOTTO, Otavio Cesar Carvalho Guimarães BAIOCCHI, Luize Meloti FIORIO +1
    Hematology, Transfusion and Cell TherapyPeer-reviewedCC BYFull textHuman geneticsDOAJ
  5. The Challenges Associated with the Diagnosis and Treatment for Aplastic Anemia Concurrent with Lymphoplasmacytic Lymphoma/Waldenström's Macroglobulinemia
    Naohiro Sekiguchi
    Internal MedicinePeer-reviewedCC BY-NC-NDFull textHuman geneticsJ-STAGE

Cite

BibTeXRIS
BibTeX
@article{wang2026waldenstroms,
  title = {{Waldenstrom's macroglobulinemia in siblings: a single institutional experience with 10 cases at 25 years and a review of the literature.}},
  author = {Lingling Wang and Yongfen Huang and Hui Chen and Jianming Dong and Hao Xu and Yuqing Miao and Yuexin Cheng},
  journal = {Annals of hematology},
  year = {2026},
  month = aug,
  doi = {10.1007/s00277-026-07249-w},
  url = {https://europepmc.org/article/MED/42911411},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Waldenstrom's macroglobulinemia in siblings: a single institutional experience with 10 cases at 25 years and a review of the literature.
AU  - Lingling Wang
AU  - Yongfen Huang
AU  - Hui Chen
AU  - Jianming Dong
AU  - Hao Xu
AU  - Yuqing Miao
AU  - Yuexin Cheng
PY  - 2026
DA  - 2026/08/01
JO  - Annals of hematology
DO  - 10.1007/s00277-026-07249-w
UR  - https://europepmc.org/article/MED/42911411
AB  - Waldenstrom's macroglobulinemia (WM) is characterized by familial aggregation. The study displayed the characteristics and outcomes of patients with WM in siblings. Ten cases (five pairs) were recognized as WM in siblings. The earliest pair (cases 3 and 4) was identified in 2002 and 2005, respectively, while the recent pair (cases 7 and 8) was confirmed in 2022. Males accounted for 90%. The median age at diagnosis was 65.5 years (range, 51-71 years). Rituximab-based immunochemotherapy was initiated in three patients, whereas regimens based on nucleoside analogs and alkylating drugs were initiated in five patients. As of December 2024, three patients died from severe infection, while one died from traumatic injury. Our investigation discovered no significant difference between WM in siblings and sporadic WM in terms of gender, age, ECOG score, B symptoms, with or without BTKi exposure, IPSS-WM score, Hb, PLT, LDH, β2-MG, IgM, albumin, hepatosplenomegaly, lymphadenopathy, and MYD88L265P. Median overall survival was 230 months for patients with familial WM among siblings and 96 months for those with sporadic WM (p = 0.2, HR: 0.6, 95% CIs: 0.2-1). This study provided an overview of the screening initiatives for WM in siblings in the hospital population and follow-up results for five pairs of WM in siblings. The incidence of WM in siblings in the real world may be underestimated.
SN  - 0939-5555
SN  - 1432-0584
ER  -