PLoS Genetics Issue Image | Vol. 22(1) October 2026
Abstract
Local heterogeneity of ATP levels within a heteroplasmic yeast zygote: A widefield fluorescence microscopy image of a heteroplasmic Saccharomyces cerevisiae zygote with its emerging daughter cell, expressing the mitochondrially targeted ratiometric ATP sensor mtQUEEN-2m, displayed as the pixel-wise 400 nm/480 nm excitation ratio. The wild-type parental cell was identified by cell-wall staining with concanavalin A–Alexa 633 prior to mating with a partner carrying mutant mtDNA. Although the parental mitochondrial networks fuse, ATP levels remain locally higher in the wild-type-derived network, suggesting that mitochondrial bioenergetics are not fully equilibrated and may locally reflect the quality of the underlying mitochondrial genome. Thoma et al. 2026
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BibTeX
@article{anon2026plos,
title = {{PLoS Genetics Issue Image | Vol. 22(1) October 2026}},
journal = {PLoS Genetics},
year = {2026},
month = oct,
doi = {10.1371/image.pgen.v22.i01},
url = {https://doi.org/10.1371/image.pgen.v22.i01},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - PLoS Genetics Issue Image | Vol. 22(1) October 2026
PY - 2026
DA - 2026/10/27
JO - PLoS Genetics
DO - 10.1371/image.pgen.v22.i01
UR - https://doi.org/10.1371/image.pgen.v22.i01
AB - Local heterogeneity of ATP levels within a heteroplasmic yeast zygote: A widefield fluorescence microscopy image of a heteroplasmic Saccharomyces cerevisiae zygote with its emerging daughter cell, expressing the mitochondrially targeted ratiometric ATP sensor mtQUEEN-2m, displayed as the pixel-wise 400 nm/480 nm excitation ratio. The wild-type parental cell was identified by cell-wall staining with concanavalin A–Alexa 633 prior to mating with a partner carrying mutant mtDNA. Although the parental mitochondrial networks fuse, ATP levels remain locally higher in the wild-type-derived network, suggesting that mitochondrial bioenergetics are not fully equilibrated and may locally reflect the quality of the underlying mitochondrial genome. Thoma et al. 2026
SN - 1553-7404
ER -