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Peer-reviewedCC BY 4.0Molecules

Reaction Studies on the Conversion of Aryl Methyl Halides to Aryl Carbonyl Compounds Using Ph4PBr/EDTA/CaF2 as a Catalytic Oxidation System

  • Xianwei Xu1
  • Sida Li1
  • Xincheng Liu1
  • Jun You1
  • Yanchao Yu1
  • Yifang Liang1
  • Wenju Wu1
  1. 1Key Laboratory of Green Chemical Engineering and Technology of College of Heilongjiang Province, College of Materials Science and Chemical Engineering, Harbin University of Science and Technology, Harbin 150080, China
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Abstract

We have developed an efficient protocol for the selective oxidation of arylmethyl halides to aromatic carbonyl compounds. This transformation employs tetraphenylphosphonium bromide (Ph4PBr) as both an oxidant and phase-transfer catalyst (PTC), in combination with EDTA and CaF2 as cocatalysts. Under mild reaction conditions, the method enables highly selective conversion of C-X bonds (X = Cl, Br) to carbonyl (C = O) functionalities. A diverse range of aromatic carbonyl products—including aldehydes, ketones, α-diketones, α-keto esters, and anhydrides—were obtained in good to excellent yields (50~95%).

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Cite

BibTeXRIS
BibTeX
@article{xu2026reaction,
  title = {{Reaction Studies on the Conversion of Aryl Methyl Halides to Aryl Carbonyl Compounds Using Ph4PBr/EDTA/CaF2 as a Catalytic Oxidation System}},
  author = {Xianwei Xu and Sida Li and Xincheng Liu and Jun You and Yanchao Yu and Yifang Liang and Wenju Wu},
  journal = {Molecules},
  year = {2026},
  month = oct,
  doi = {10.3390/molecules31203742},
  url = {https://www.mdpi.com/1420-3049/31/20/3742},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Reaction Studies on the Conversion of Aryl Methyl Halides to Aryl Carbonyl Compounds Using Ph4PBr/EDTA/CaF2 as a Catalytic Oxidation System
AU  - Xianwei Xu
AU  - Sida Li
AU  - Xincheng Liu
AU  - Jun You
AU  - Yanchao Yu
AU  - Yifang Liang
AU  - Wenju Wu
PY  - 2026
DA  - 2026/10/18
JO  - Molecules
DO  - 10.3390/molecules31203742
UR  - https://www.mdpi.com/1420-3049/31/20/3742
AB  - We have developed an efficient protocol for the selective oxidation of arylmethyl halides to aromatic carbonyl compounds. This transformation employs tetraphenylphosphonium bromide (Ph4PBr) as both an oxidant and phase-transfer catalyst (PTC), in combination with EDTA and CaF2 as cocatalysts. Under mild reaction conditions, the method enables highly selective conversion of C-X bonds (X = Cl, Br) to carbonyl (C = O) functionalities. A diverse range of aromatic carbonyl products—including aldehydes, ketones, α-diketones, α-keto esters, and anhydrides—were obtained in good to excellent yields (50~95%).
SN  - 1420-3049
ER  -