Fabrication and Preliminary in vivo Evaluation of a Cerium Dioxide Nanoparticle-Loaded Degradable PLGA Nanofiber Dressing for Burn Wound Healing.
- 1Department of Plastic and Reconstructive Surgery, Keelung and Linkou Chang-Gung Memorial Hospital, Chang-Gung University and Medical College, Taoyuan, 33302, Taiwan.
- 2Department of Mechanical Engineering, Chang Gung University, Taoyuan, 33302, Taiwan.
- 3Department of Orthopedic Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, 33305, Taiwan.
Abstract
Background
Conventional burn dressings maintain a moist wound environment and reduce infection but do not directly counteract the sustained oxidative stress and inflammation of the burn wound bed. Cerium dioxide (CeO₂) nanoparticles possess redox-based antioxidant activity, motivating their incorporation into a resorbable dressing. This study aimed to fabricate and preliminarily evaluate CeO₂-loaded poly(lactic-co-glycolic acid) (PLGA) nanofiber dressings for burn wound healing.Methods
CeO₂-loaded and pristine PLGA nanofibers were produced by electrospinning and characterized for fiber morphology, elemental composition, tensile properties, wettability, water uptake, and in vitro cytocompatibility. Wound healing was assessed in a full-thickness rat burn model over 28 days, with histological analysis at days 7 and 28.Results
CeO₂-incorporated nanofibers showed a smaller average fiber diameter (159.8 ± 97.6 nm) than pristine PLGA nanofibers (267.9 ± 146.3 nm). CeO₂ incorporation reduced tensile strength, although all fibers retained good elongation (> 50%) before fracture. In vivo, the CeO₂-loaded nanofibers produced a transient reduction in wound area that was significantly greater than the control at days 14 and 21 and greater than pristine PLGA at day 14 (p < 0.05); by day 28, wound areas had converged and the differences among groups were no longer statistically significant. Histological analysis showed earlier collagen deposition and no adverse tissue response.Conclusion
CeO₂-loaded PLGA nanofiber dressings are biocompatible and can accelerate the intermediate phase of burn wound closure in a rat model. Because the CeO₂ redox state, CeO₂ release, and in vivo antioxidant mechanisms were not directly measured, the improvement cannot yet be causally attributed to CeO₂, and further mechanistic studies are required.
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BibTeX
@article{chen2026fabrication,
title = {{Fabrication and Preliminary in vivo Evaluation of a Cerium Dioxide Nanoparticle-Loaded Degradable PLGA Nanofiber Dressing for Burn Wound Healing.}},
author = {Shih-Heng Chen and Ching-Yu Lan and Hao-Chen Hung and Rifky Rahardian Setiawan and Shih-Jung Liu},
journal = {International journal of nanomedicine},
year = {2026},
month = oct,
doi = {10.2147/ijn.s645988},
url = {https://europepmc.org/article/MED/42928828},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Fabrication and Preliminary in vivo Evaluation of a Cerium Dioxide Nanoparticle-Loaded Degradable PLGA Nanofiber Dressing for Burn Wound Healing.
AU - Shih-Heng Chen
AU - Ching-Yu Lan
AU - Hao-Chen Hung
AU - Rifky Rahardian Setiawan
AU - Shih-Jung Liu
PY - 2026
DA - 2026/10/21
JO - International journal of nanomedicine
DO - 10.2147/ijn.s645988
UR - https://europepmc.org/article/MED/42928828
AB - Background Conventional burn dressings maintain a moist wound environment and reduce infection but do not directly counteract the sustained oxidative stress and inflammation of the burn wound bed. Cerium dioxide (CeO₂) nanoparticles possess redox-based antioxidant activity, motivating their incorporation into a resorbable dressing. This study aimed to fabricate and preliminarily evaluate CeO₂-loaded poly(lactic-co-glycolic acid) (PLGA) nanofiber dressings for burn wound healing.Methods CeO₂-loaded and pristine PLGA nanofibers were produced by electrospinning and characterized for fiber morphology, elemental composition, tensile properties, wettability, water uptake, and in vitro cytocompatibility. Wound healing was assessed in a full-thickness rat burn model over 28 days, with histological analysis at days 7 and 28.Results CeO₂-incorporated nanofibers showed a smaller average fiber diameter (159.8 ± 97.6 nm) than pristine PLGA nanofibers (267.9 ± 146.3 nm). CeO₂ incorporation reduced tensile strength, although all fibers retained good elongation (> 50%) before fracture. In vivo, the CeO₂-loaded nanofibers produced a transient reduction in wound area that was significantly greater than the control at days 14 and 21 and greater than pristine PLGA at day 14 (p < 0.05); by day 28, wound areas had converged and the differences among groups were no longer statistically significant. Histological analysis showed earlier collagen deposition and no adverse tissue response.Conclusion CeO₂-loaded PLGA nanofiber dressings are biocompatible and can accelerate the intermediate phase of burn wound closure in a rat model. Because the CeO₂ redox state, CeO₂ release, and in vivo antioxidant mechanisms were not directly measured, the improvement cannot yet be causally attributed to CeO₂, and further mechanistic studies are required.
SN - 1176-9114
SN - 1178-2013
ER -