Influence of Dietary Rumen-Protected Choline and Nicotinic Acid Supplementation on Growth Outcomes and Meat Tenderness, Rumen Microbial Composition, and Serum Metabolomics of Late-Fattening Beef Cattle.
5 affiliations
- 1College of Modern Beef Cattle Industry, College of Food Science and Engineering, Shandong Agriculture and Engineering University, Jinan 250100, China.
- 2College of Food Science and Engineering, Shandong Agricultural University, Tai'an 271018, China.
- 3College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
- 4College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China.
- 5Key Laboratory of Novel Food Resources Processing, Institute of Agro-Food Sciences and Technology, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Abstract
High-concentrate feeding during late fattening can impair metabolic health and meat quality in beef cattle, yet effective nutritional strategies remain limited. Choline and nicotinic acid are involved in lipid and energy metabolism, but information on their combined or sequential supplementation is scarce. This study evaluated rumen-protected choline given alone or together with nicotinic acid on growth performance, meat quality, serum biochemical indices, serum metabolomics, and free amino acid profiles in late-fattening beef cattle. Twenty-four black cattle were randomly allocated to three groups: CON (basal diet), CC (basal diet + 10 g/d RPC for 90 d), and CC-CNA (basal diet + 10 g/d RPC for 90 d + 10 g/d protected NA during the final 30 d). Shear force was significantly lower in both CC and CC-CNA than in CON (p < 0.05), indicating improved tenderness. Exploratory serum metabolomics identified treatment-associated metabolites and pathways related to amino acid, purine, sphingolipid, and lipid metabolism. Taste-related free amino acids were also altered by supplementation (p < 0.05). RPC alone or with short-term NA may improve tenderness and modulate systemic metabolic responses; larger studies with direct sensory evaluation are needed to confirm growth and flavor-related effects.
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BibTeX
@article{xu2026influence,
title = {{Influence of Dietary Rumen-Protected Choline and Nicotinic Acid Supplementation on Growth Outcomes and Meat Tenderness, Rumen Microbial Composition, and Serum Metabolomics of Late-Fattening Beef Cattle.}},
author = {Baochen Xu and Tianyu Gao and Xiaoyan Wang and Mengqi Li and Xuekuan Hui and Yanxia Xing and Yang Li and Lizeng Peng and He Zhu and Dong Chen},
journal = {Animals : an open access journal from MDPI},
year = {2026},
month = oct,
doi = {10.3390/ani16193144},
url = {https://europepmc.org/article/MED/42883114},
note = {CC BY},
}
RIS
TY - JOUR
TI - Influence of Dietary Rumen-Protected Choline and Nicotinic Acid Supplementation on Growth Outcomes and Meat Tenderness, Rumen Microbial Composition, and Serum Metabolomics of Late-Fattening Beef Cattle.
AU - Baochen Xu
AU - Tianyu Gao
AU - Xiaoyan Wang
AU - Mengqi Li
AU - Xuekuan Hui
AU - Yanxia Xing
AU - Yang Li
AU - Lizeng Peng
AU - He Zhu
AU - Dong Chen
PY - 2026
DA - 2026/10/08
JO - Animals : an open access journal from MDPI
DO - 10.3390/ani16193144
UR - https://europepmc.org/article/MED/42883114
AB - High-concentrate feeding during late fattening can impair metabolic health and meat quality in beef cattle, yet effective nutritional strategies remain limited. Choline and nicotinic acid are involved in lipid and energy metabolism, but information on their combined or sequential supplementation is scarce. This study evaluated rumen-protected choline given alone or together with nicotinic acid on growth performance, meat quality, serum biochemical indices, serum metabolomics, and free amino acid profiles in late-fattening beef cattle. Twenty-four black cattle were randomly allocated to three groups: CON (basal diet), CC (basal diet + 10 g/d RPC for 90 d), and CC-CNA (basal diet + 10 g/d RPC for 90 d + 10 g/d protected NA during the final 30 d). Shear force was significantly lower in both CC and CC-CNA than in CON (p < 0.05), indicating improved tenderness. Exploratory serum metabolomics identified treatment-associated metabolites and pathways related to amino acid, purine, sphingolipid, and lipid metabolism. Taste-related free amino acids were also altered by supplementation (p < 0.05). RPC alone or with short-term NA may improve tenderness and modulate systemic metabolic responses; larger studies with direct sensory evaluation are needed to confirm growth and flavor-related effects.
SN - 2076-2615
ER -