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Peer-reviewedCC BYJournal of nanobiotechnology

Advances in osteogenic niche engineering: integrating topography and electrical cues for bone repair and regeneration.

  • Jingyan Huang1
  • Dongheng Lu1
  • Yixuan Liu1
  • Taras Vladimirovich Furtsev2
  • Peng Yu3
  • Chenye Hou1
  • Xiaoshuang Wang1
  • Weichang Li4
  • Yan Wang5
5 affiliations
  1. 1Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China.
  2. 2Department of Orthopedic Dentistry, Faculty of Dentistry, Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.
  3. 3School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510641, China.
  4. 4Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China. [email protected].
  5. 5Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China. [email protected].
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Abstract

Bone defects caused by aging and trauma present significant clinical challenges, driving intense research into bone regeneration strategies. Cellular behaviour during bone repair is critically regulated by the sustainable biophysical cues of the bone niche, particularly topography and electrical signals. Recent advances in biomaterial engineering now enable the precise modulation of these microenvironmental factors-through tuneable topographical and electroactive interfaces-to promote osteogenesis. This review examines emerging evidence on the individual and synergistic roles of surface topography and electrical stimulation in bone regeneration, highlighting their potential as non-pharmacological therapeutic approaches.

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Cite

BibTeXRIS
BibTeX
@article{huang2026advances,
  title = {{Advances in osteogenic niche engineering: integrating topography and electrical cues for bone repair and regeneration.}},
  author = {Jingyan Huang and Dongheng Lu and Yixuan Liu and Taras Vladimirovich Furtsev and Peng Yu and Chenye Hou and Xiaoshuang Wang and Weichang Li and Yan Wang},
  journal = {Journal of nanobiotechnology},
  year = {2026},
  month = aug,
  doi = {10.1186/s12951-026-04852-x},
  url = {https://europepmc.org/article/MED/42958509},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Advances in osteogenic niche engineering: integrating topography and electrical cues for bone repair and regeneration.
AU  - Jingyan Huang
AU  - Dongheng Lu
AU  - Yixuan Liu
AU  - Taras Vladimirovich Furtsev
AU  - Peng Yu
AU  - Chenye Hou
AU  - Xiaoshuang Wang
AU  - Weichang Li
AU  - Yan Wang
PY  - 2026
DA  - 2026/08/01
JO  - Journal of nanobiotechnology
DO  - 10.1186/s12951-026-04852-x
UR  - https://europepmc.org/article/MED/42958509
AB  - Bone defects caused by aging and trauma present significant clinical challenges, driving intense research into bone regeneration strategies. Cellular behaviour during bone repair is critically regulated by the sustainable biophysical cues of the bone niche, particularly topography and electrical signals. Recent advances in biomaterial engineering now enable the precise modulation of these microenvironmental factors-through tuneable topographical and electroactive interfaces-to promote osteogenesis. This review examines emerging evidence on the individual and synergistic roles of surface topography and electrical stimulation in bone regeneration, highlighting their potential as non-pharmacological therapeutic approaches.
SN  - 1477-3155
ER  -