Recent Advances in the Preparation of Deuterium-Labeled Chemicals via Heterogeneous Catalysis
- 1State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, Liaoning Key Laboratory for Catalytic Conversion of CarbonResources, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China
Abstract
Deuterium-labeled compounds play an irreplaceable role in fields such as medicine R&D，analytical testing，and materials science. There is an urgent need to develop efficient deuteration methods to address the challenges faced in the preparation of deuterium-labeled compounds，including high costs of deuterium sources，lengthy synthesis routes，and difficulties in catalyst recovery. In recent years，heterogeneous catalytic strategies using deuterium oxide (D2O) as deuterium source have garnered significant attention due to their advantages，including catalyst recoverability and the low cost and easy availability of the deuterium source. Based on the different types of reaction substrates，this work summarizes the progress in site-selective deuteration and perdeuteration of substrates such as arenes，heteroarenes，and aliphatic compounds via heterogeneous catalysis. It particularly analyzes the relationships among the unique surface active site structures, metal-support interactions，substrate adsorption configurations，and deuteration selectivity in heterogeneous catalysis. In the future，the development of low-load noble-metal catalytic systems，non-noble-metal catalytic systems，functional additives，and mild catalytic deuteration methods based on low-cost deuterium sources will represent important research directions in deuteration technology.
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BibTeX
@article{zhao2026recent,
title = {{Recent Advances in the Preparation of Deuterium-Labeled Chemicals via Heterogeneous Catalysis}},
author = {Zimeng ZHAO and Fujia GAO and Xiangyi LIU and Guangping HAO},
journal = {Journal of Isotopes},
year = {2026},
month = oct,
doi = {10.7538/tws.2026.youxian.069},
url = {https://doi.org/10.7538/tws.2026.youxian.069},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Recent Advances in the Preparation of Deuterium-Labeled Chemicals via Heterogeneous Catalysis
AU - Zimeng ZHAO
AU - Fujia GAO
AU - Xiangyi LIU
AU - Guangping HAO
PY - 2026
DA - 2026/10/26
JO - Journal of Isotopes
DO - 10.7538/tws.2026.youxian.069
UR - https://doi.org/10.7538/tws.2026.youxian.069
AB - Deuterium-labeled compounds play an irreplaceable role in fields such as medicine R&D，analytical testing，and materials science. There is an urgent need to develop efficient deuteration methods to address the challenges faced in the preparation of deuterium-labeled compounds，including high costs of deuterium sources，lengthy synthesis routes，and difficulties in catalyst recovery. In recent years，heterogeneous catalytic strategies using deuterium oxide (D2O) as deuterium source have garnered significant attention due to their advantages，including catalyst recoverability and the low cost and easy availability of the deuterium source. Based on the different types of reaction substrates，this work summarizes the progress in site-selective deuteration and perdeuteration of substrates such as arenes，heteroarenes，and aliphatic compounds via heterogeneous catalysis. It particularly analyzes the relationships among the unique surface active site structures, metal-support interactions，substrate adsorption configurations，and deuteration selectivity in heterogeneous catalysis. In the future，the development of low-load noble-metal catalytic systems，non-noble-metal catalytic systems，functional additives，and mild catalytic deuteration methods based on low-cost deuterium sources will represent important research directions in deuteration technology.
SN - 1000-7512
ER -