Polygonatum cyrtonema Hua in Jiuhua Mountain: Structural Characterization and Biological Activity
- 1School of Bioengineering, , Huainan 232038, China
- 2College of Life and Environmental Sciences, , Huangshan 245700, China
- 3School of Tourism, , Huangshan 245700, China
Abstract
Polygonatum cyrtonema Hua in Jiuhua Mountain (JHPCH) is a nationally recognized geographically indicated medicinal plant known for its bioactive polysaccharides with diverse pharmacological activities. This study isolated a homogeneous polysaccharide JPCP-70-0 from JHPCH via hot water extraction, ethanol precipitation, and chromatographic purification. Structural characterization by GC-MS, FT-IR, and NMR identified it as a neutral fructan (2.88 × 104 Da) with Glc/Fru (6.65%/93.35%), a backbone of →1)-β-D-Fruf-(2→, and side chains of →6)-β-D-Fruf-(2→). Using Caenorhabditis elegans as a model, we evaluated JPCP-70-0’s effects on nematode growth. Results showed concentration-dependent regulation: low concentrations promoted growth, locomotion, feeding, and reproduction, while high concentrations induced developmental inhibition and reduced activity. This work provides a theoretical basis for the rational development of JHPCH resources.
Related
- Antimony(III) and Bismuth(III) Halide Complexes Containing Thiazole-and Thiadiazole-Based Mercapto Ligands: Synthesis, Structural Characterization, and Biological Activity
- Tetrahedral DNA Nanostructures: A Structural-Family-Aware Review from Computational Design and Biological Stability to Translational Nanomedicine
- Synthesis, characterization and biological evaluation of newly designed silver(I)-N-heterocyclic carbene (NHC) complexes
- Recent advances in the synthesis, structural diversification, and biological evaluation of sulfamethoxazole derivatives.
- Mercury(II) Coordination Compounds Based on Pyridine-2,5-Dicarboxylic Acid: Synthesis, Crystal Structure, Morphological Characterization, and Biological Activities.
BibTeX
@article{geng2026polygonatum,
title = {{Polygonatum cyrtonema Hua in Jiuhua Mountain: Structural Characterization and Biological Activity}},
author = {Xueqing Geng and Xingchi Zhang and Yun Wang and Ting Yao and Zhuoting Gan},
journal = {Molecules (Basel, Switzerland)},
year = {2026},
month = oct,
doi = {10.3390/molecules31193542},
url = {https://europepmc.org/article/PMC/PMC13667172},
note = {CC BY},
}
RIS
TY - JOUR
TI - Polygonatum cyrtonema Hua in Jiuhua Mountain: Structural Characterization and Biological Activity
AU - Xueqing Geng
AU - Xingchi Zhang
AU - Yun Wang
AU - Ting Yao
AU - Zhuoting Gan
PY - 2026
DA - 2026/10/01
JO - Molecules (Basel, Switzerland)
DO - 10.3390/molecules31193542
UR - https://europepmc.org/article/PMC/PMC13667172
AB - Polygonatum cyrtonema Hua in Jiuhua Mountain (JHPCH) is a nationally recognized geographically indicated medicinal plant known for its bioactive polysaccharides with diverse pharmacological activities. This study isolated a homogeneous polysaccharide JPCP-70-0 from JHPCH via hot water extraction, ethanol precipitation, and chromatographic purification. Structural characterization by GC-MS, FT-IR, and NMR identified it as a neutral fructan (2.88 × 104 Da) with Glc/Fru (6.65%/93.35%), a backbone of →1)-β-D-Fruf-(2→, and side chains of →6)-β-D-Fruf-(2→). Using Caenorhabditis elegans as a model, we evaluated JPCP-70-0’s effects on nematode growth. Results showed concentration-dependent regulation: low concentrations promoted growth, locomotion, feeding, and reproduction, while high concentrations induced developmental inhibition and reduced activity. This work provides a theoretical basis for the rational development of JHPCH resources.
SN - 1420-3049
ER -