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Peer-reviewedCC BY-NC-ND 4.0ACS Omega

Biomimetic Fabrication and Osteogenic Efficacy Evaluation of Tilapia-Derived Collagen-Based Artificial Bone Scaffolds

  • Lei Wang1
  • Jing Zhu2
  • Xiaorui Jiang3
  • Kai Wang3
  1. 1Affiliated Hospital of Shandong Second Medical University , , ,
  2. 2Shandong First Medical University , , , ,
  3. 3The Affiliated Yantai Yuhuangding Hospital of Qingdao University , , , ,
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Abstract

Inspired by the natural biomineralization processes observed in terrestrial vertebrates, this study independently designed an in vitro mineralization system to activate nucleation sites within tilapia fish collagen, facilitating the fabrication of biomimetic bone substitutes. Through lyophilization and molding techniques, a three-dimensional porous scaffold with a defined spatial architecture and adequate mechanical integrity was successfully constructed. Subsequently, the physicochemical properties, biocompatibility, and biodegradation characteristics of the prepared fish collagen-based artificial bone (FC-AB) were evaluated and compared to relevant standards. Furthermore, a rat tibial critical-sized defect model was employed to assess the in vivo bone regeneration capacity. The results demonstrated that the FC-AB scaffold possesses an ideal porous microstructure, excellent biocompatibility, and controllable degradation characteristics. Notably, it significantly promoted the osteogenesis and functional restoration of the bone defect. In conclusion, this research confirms the feasibility of utilizing fish collagen as a precursor for in vitro mineralization, yielding artificial bone materials with superior structural mimicry, mechanical competence, and osteoinductive potential, thereby positioning it as a promising candidate for bone tissue engineering.

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Cite

BibTeXRIS
BibTeX
@article{wang2026biomimetic,
  title = {{Biomimetic Fabrication and Osteogenic Efficacy Evaluation of Tilapia-Derived Collagen-Based Artificial Bone Scaffolds}},
  author = {Lei Wang and Jing Zhu and Xiaorui Jiang and Kai Wang},
  journal = {ACS Omega},
  year = {2026},
  month = nov,
  doi = {10.1021/acsomega.6c07910},
  url = {https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c07910/5464755/Biomimetic-Fabrication-and-Osteogenic-Efficacy},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Biomimetic Fabrication and Osteogenic Efficacy Evaluation of Tilapia-Derived Collagen-Based Artificial Bone Scaffolds
AU  - Lei Wang
AU  - Jing Zhu
AU  - Xiaorui Jiang
AU  - Kai Wang
PY  - 2026
DA  - 2026/11/05
JO  - ACS Omega
DO  - 10.1021/acsomega.6c07910
UR  - https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c07910/5464755/Biomimetic-Fabrication-and-Osteogenic-Efficacy
AB  - Inspired by the natural biomineralization processes observed in terrestrial vertebrates, this study independently designed an in vitro mineralization system to activate nucleation sites within tilapia fish collagen, facilitating the fabrication of biomimetic bone substitutes. Through lyophilization and molding techniques, a three-dimensional porous scaffold with a defined spatial architecture and adequate mechanical integrity was successfully constructed. Subsequently, the physicochemical properties, biocompatibility, and biodegradation characteristics of the prepared fish collagen-based artificial bone (FC-AB) were evaluated and compared to relevant standards. Furthermore, a rat tibial critical-sized defect model was employed to assess the in vivo bone regeneration capacity. The results demonstrated that the FC-AB scaffold possesses an ideal porous microstructure, excellent biocompatibility, and controllable degradation characteristics. Notably, it significantly promoted the osteogenesis and functional restoration of the bone defect. In conclusion, this research confirms the feasibility of utilizing fish collagen as a precursor for in vitro mineralization, yielding artificial bone materials with superior structural mimicry, mechanical competence, and osteoinductive potential, thereby positioning it as a promising candidate for bone tissue engineering.
SN  - 2470-1343
ER  -