Comparative Evaluation of Tyrosinase Inhibitory Activity in Taxonomically Verified Wood-Inhabiting Fungi
- 1School of Biological Sciences and Institute of Biodiversity, Seoul National University, Seoul, Republic of Korea.
- 2Department of Microbiology, Parasitology and Biotechnology, Sokoine University of Agriculture, Morogoro, Tanzania.
Abstract
Wood-inhabiting fungi represent a taxonomically and metabolically diverse group with potential as sources of bioactive compounds, yet their tyrosinase inhibitory activity remains poorly explored beyond a limited number of well-known medicinal species. In this study, we comparatively evaluated the tyrosinase inhibitory activity of cultured mycelial extracts from 49 phylogenetically verified strains of wood-inhabiting fungi belonging to the Hymenochaetales and Polyporales orders. Strains were cultivated under standardized conditions, and ethanol extracts prepared from three independent biological replicates were evaluated at concentrations of 0.1, 0.5, 1, and 5 mg/mL. Tyrosinase inhibitory activity varied markedly among the tested strains and generally increased with extract concentration. Hydnophlebia alachuana and Nigroporus vinosus showed particularly high activity, including substantial inhibition at the lowest concentration tested. These findings expand the range of wood-inhabiting fungi evaluated for tyrosinase inhibition and identify previously underexplored taxa as promising candidates for further investigation. The results provide a basis for prioritizing active fungal strains for chemical characterization and further evaluation of their tyrosinase-inhibitory potential.
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BibTeX
@article{lupala2026comparative,
title = {{Comparative Evaluation of Tyrosinase Inhibitory Activity in Taxonomically Verified Wood-Inhabiting Fungi}},
author = {Abel Severin Lupala and Jiyun Choi and Ji Seon Kim and Young Woon Lim},
journal = {Mycobiology},
year = {2026},
month = oct,
doi = {10.1080/12298093.2026.2745388},
url = {https://europepmc.org/article/PMC/PMC13726307},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Comparative Evaluation of Tyrosinase Inhibitory Activity in Taxonomically Verified Wood-Inhabiting Fungi
AU - Abel Severin Lupala
AU - Jiyun Choi
AU - Ji Seon Kim
AU - Young Woon Lim
PY - 2026
DA - 2026/10/31
JO - Mycobiology
DO - 10.1080/12298093.2026.2745388
UR - https://europepmc.org/article/PMC/PMC13726307
AB - Wood-inhabiting fungi represent a taxonomically and metabolically diverse group with potential as sources of bioactive compounds, yet their tyrosinase inhibitory activity remains poorly explored beyond a limited number of well-known medicinal species. In this study, we comparatively evaluated the tyrosinase inhibitory activity of cultured mycelial extracts from 49 phylogenetically verified strains of wood-inhabiting fungi belonging to the Hymenochaetales and Polyporales orders. Strains were cultivated under standardized conditions, and ethanol extracts prepared from three independent biological replicates were evaluated at concentrations of 0.1, 0.5, 1, and 5 mg/mL. Tyrosinase inhibitory activity varied markedly among the tested strains and generally increased with extract concentration. Hydnophlebia alachuana and Nigroporus vinosus showed particularly high activity, including substantial inhibition at the lowest concentration tested. These findings expand the range of wood-inhabiting fungi evaluated for tyrosinase inhibition and identify previously underexplored taxa as promising candidates for further investigation. The results provide a basis for prioritizing active fungal strains for chemical characterization and further evaluation of their tyrosinase-inhibitory potential.
SN - 1229-8093
SN - 2092-9323
ER -